Efficacy of intraoperative intravenous lidocaine infusion on postoperative opioid consumption after laparoscopic cholecystectomy: a randomized controlled trial.

Autor: Sarakatsianou C; Department of Anaesthesiology, University Hospital of Larissa, Mezourlo, 41110, Larissa, Greece. heidisarak@gmail.com., Perivoliotis K; Department of Surgery, General Hospital of Volos, Polymeri 134, 38222, Volos, Greece., Baloyiannis I; Department of Surgery, University Hospital of Larissa, Mezourlo, 41110, Larissa, Greece., Georgopoulou S; Department of Anaesthesiology, University Hospital of Larissa, Mezourlo, 41110, Larissa, Greece., Tsiaka A; Department of Anaesthesiology, University Hospital of Larissa, Mezourlo, 41110, Larissa, Greece., Tzovaras G; Department of Surgery, University Hospital of Larissa, Mezourlo, 41110, Larissa, Greece.
Jazyk: angličtina
Zdroj: Langenbeck's archives of surgery [Langenbecks Arch Surg] 2023 May 18; Vol. 408 (1), pp. 197. Date of Electronic Publication: 2023 May 18.
DOI: 10.1007/s00423-023-02937-x
Abstrakt: Purpose: We designed this study to evaluate the impact of intraoperative intravenous lidocaine infusion on postoperative opioid consumption after laparoscopic cholecystectomy.
Methods: In total, 98 patients scheduled for elective laparoscopic cholecystectomy were included and randomized. In the experimental group, intravenous lidocaine (bolus 1.5 mg/kg and continuous infusion 2 mg/kg/h) was administered intraoperatively additionally to the standard analgesia, whereas the control group received a matching placebo. Blinding existed at the level of both the patient and the investigator.
Results: Our study failed to confirm any benefit in opioid consumption, during the postoperative period. Lidocaine resulted to reduced intraoperative systolic, diastolic, and mean arterial pressure. Lidocaine administration did not change postoperative pain scores or the incidence of shoulder pain, at any time endpoint. Moreover, we did not identify any difference in terms of postoperative sedation levels and nausea rates.
Conclusion: Overall, lidocaine did not have any effect on postoperative analgesia after laparoscopic cholecystectomy.
(© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
Databáze: MEDLINE
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