Seasonality of sporotrichosis in Brazil: A modelled analysis of the epidemic in São Paulo, 2011-2020.

Autor: de Freitas VLT; Department of Infectious and Parasitic Diseases, Medical School, University of Sao Paulo, Sao Paulo, Brazil., Rocha FMM; Paulista School of Politics, Economics and Business, Federal University of São Paulo, São Paulo, Brazil., Ribeiro EN; Medical Mycology Laboratory (LIM 53/HCFMUSP) and Institute Tropical Medicine, University of Sao Paulo, Sao Paulo, Brazil., Lindoso JAL; Laboratory of Protozoology (LIM 49/HCFMUSP), Institute of Tropical Medicine, Medical School, University of São Paulo, São Paulo, Brazil.; Emilio Ribas Institute of Infectious Diseases, São Paulo, Brazil., Bittencourt AA; Emilio Ribas Institute of Infectious Diseases, São Paulo, Brazil., Pivetta DNAG; Medical Mycology Laboratory (LIM 53/HCFMUSP) and Institute Tropical Medicine, University of Sao Paulo, Sao Paulo, Brazil., Benard G; Medical Mycology Laboratory (LIM 53/HCFMUSP) and Institute Tropical Medicine, University of Sao Paulo, Sao Paulo, Brazil., de Freitas-Xavier RS; Medical Mycology Laboratory (LIM 53/HCFMUSP) and Institute Tropical Medicine, University of Sao Paulo, Sao Paulo, Brazil.
Jazyk: angličtina
Zdroj: Mycoses [Mycoses] 2023 Aug; Vol. 66 (8), pp. 643-650. Date of Electronic Publication: 2023 May 17.
DOI: 10.1111/myc.13594
Abstrakt: Background: Sporotrichosis is an endemic subcutaneous mycosis classically caused by the Sporothrix schenckii species complex. Recently, sporotrichosis has emerged in Brazil as a cat-transmitted epidemic caused by a new species, Sporothrix brasiliensis.
Objectives: To survey the clinical-epidemiological profile of all sporotrichosis cases diagnosed between 2011 and 2020 at a reference hospital in São Paulo metropolitan area and evaluate the annual distribution of cases in relation to seasonality.
Methods: Patients' demographic and clinical-epidemiological data were surveyed. A generalized linear model was fitted to relate the quarterly number of sporotrichosis cases detected between 2015 and 2019 with precipitation and temperature series. Prediction of the number of cases from 2011 to 2014 was attempted based on the fitted model without the trend component that appears from 2015.
Results: Among 271 suspected cases admitted during 2011-2020, 254 were confirmed by fungal isolation and/or clinical-epidemiological criteria. We observed that 2015 onwards the number of cases regularly increased during Autumn and Winter, the driest and coldest stations of the year. We verified that temperature series affected the number of cases (p = .005) because an increase of 1°C in the temperature series was associated with a 14.24% decrease in the average cases number, with the average number of cases increasing by 10.96% (p < .0001) every quarter, corresponding to an annual increase of 52%. Between 2011 and 2014, the predicted number of sporotrichosis cases averaged 10-12 per year, with 33%-38% occurring in the winter.
Conclusion: We hypothesize that sporotrichosis seasonality is associated with the felines' oestrus cycle, which may provide alternative, cat-directed approaches to the sporotrichosis epidemic control.
(© 2023 Wiley-VCH GmbH. Published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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