Gaps in the Care of Subjects with Familial Hypercholesterolemia: Insights from the Thai Familial Hypercholesterolemia Registry.

Autor:	Ganokroj P; Department of Laboratory Medicine, King Chulalongkorn Memorial Hospital and Chulalongkorn University., Muanpetch S; Department of Medicine, King Chulalongkorn Memorial Hospital., Deerochanawong C; Department of Medicine, Rajavithi Hospital and Rangsit University., Phimphilai M; Department of Medicine, Maharaj Nakorn Chiang Mai Hospital, Chiang Mai University., Leelawattana R; Department of Medicine, Songklanagarind Hospital, Prince of Songkla University., Thongtang N; Department of Medicine, Siriraj Hospital, Mahidol University., Krittayaphong R; Department of Medicine, Siriraj Hospital, Mahidol University., Anthanont P; Department of Medicine, Thammasat Hospital, Thammasat University., Vathesatogkit P; Department of Medicine, Ramathibodi Hospital, Mahidol University., Sriphrapradang C; Department of Medicine, Ramathibodi Hospital, Mahidol University., Senthong V; Department of Medicine, Srinagarind Hospital, Khon Kaen University., Torpongpun A; Department of Medicine, Chonburi Hospital, Ministry of Public Health., Suteerayongprasert P; Department of Medicine, Chonburi Hospital, Ministry of Public Health., Pengpong N; Department of Medicine, King Prajadhipok Memorial Hospital., Sathavarodom N; Department of Medicine, Phramongkutklao Hospital and College of Medicine., Sunanta U; Department of Medicine, Bhumibol Adulyadej Hospital., Porntharukchareon T; Department of Medicine, Chulabhorn Hospital, Chulabhorn Royal Academy., Kiatpanabhikul P; Department of Medicine, Charoenkrung Pracharak Hospital, Bangkok Metropolitan Administration., Kaewkrasaesin C; Department of Medicine, Taksin Hospital, Bangkok Metropolitan Administration., Suraamornkul S; Department of Medicine, Vajira Hospital, Navamindradhiraj University., Kongkit J; Department of Medicine, Vachira Phuket Hospital, Ministry of Public Health., Umphonsathien M; Department of Medicine, Police General Hospital., Chattranukulchai P; Department of Medicine, King Chulalongkorn Memorial Hospital and Chulalongkorn University., Jiamjarasrungsi W; Department of Preventive and Social Medicine, King Chulalongkorn Memorial Hospital and Chulalongkorn University., Khovidhunkit W; Department of Medicine, King Chulalongkorn Memorial Hospital and Chulalongkorn University.
Jazyk:	angličtina
Zdroj:	Journal of atherosclerosis and thrombosis [J Atheroscler Thromb] 2023 Dec 01; Vol. 30 (12), pp. 1803-1816. Date of Electronic Publication: 2023 May 18.
DOI:	10.5551/jat.64081
Abstrakt:	Aims: Familial hypercholesterolemia (FH) is currently underdiagnosed and undertreated. The establishment of a FH registry could facilitate a deeper understanding of this disease. We described the clinical characteristics of subjects with FH from the Thai FH Registry, compared our data with the regional and global data, and identified gaps in the care of these subjects. Methods: A multicenter, nationwide prospective FH registry was established in Thailand. Our data were compared with those of the European Atherosclerosis Society-FH Studies Collaboration. Multiple logistic regression analyses were performed for variables associated with lipid-lowering medication (LLM) use and the attainment of low-density lipoprotein-cholesterol (LDL-C) goal. Results: The study includes 472 subjects with FH (mean age at FH diagnosis: 46±12 years, 61.4% women). A history of premature coronary artery disease was found in 12%. The percentage of LLM use in subjects with a Dutch Lipid Clinic Network score of ≥ 6 (probable or definite FH) in our registry (64%) was slightly lower than the regional data but higher than the global data. Among those who received statins, 25.2% and 6.4% achieved LDL-C levels of ＜100 mg/dL and ＜70 mg/dL, respectively. Women with FH were less likely to achieve LDL-C ＜70 mg/dL (adjusted odds ratio: 0.22, 95% confidence interval: 0.06-0.71, p=0.012). Conclusions: FH in Thailand was diagnosed late, and treatment was inadequate for the majority of subjects. Women with FH were less likely to achieve LDL-C goals. Our insights could potentially help raise awareness and narrow the gap in patient care.
Databáze:	MEDLINE
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