ADAMS project: a genetic Association study in individuals from Diverse Ancestral backgrounds with Multiple Sclerosis based in the UK.

Autor:	Jacobs BM; Preventive Neurology Unit, Wolfson Institute of Population Health, Queen Mary University of London, London, UK., Schalk L; Preventive Neurology Unit, Wolfson Institute of Population Health, Queen Mary University of London, London, UK., Dunne A; Leeds Centre for Neurosciences, Leeds teaching Hospitals NHS Trust, Leeds, UK., Scalfari A; Centre of Neuroscience, Department of Medicine, Imperial College London, London, UK., Nandoskar A; Hillingdon and Imperial NHS Trust, London, UK., Gran B; Department of Neurology, Nottingham University Hospitals NHS Trust, Mental Health and Clinical Neuroscience Academic Unit, University of Nottingham School of Medicine, Nottingham, UK., Mein CA; Barts and the London Genome Centre, Queen Mary University of London, London, UK., Sellers C; Preventive Neurology Unit, Wolfson Institute of Population Health, Queen Mary University of London, London, UK., Spilker C; Bradford Teaching Hospital Foundation Trust, Bradford, UK., Rog D; Manchester Centre for Clinical Neurosciences, Northern Care Alliance NHS Trust, Manchester, UK., Visentin E; Research and Innovation, Queen's Hospital, BHRUT, London, UK., Bezzina EL; Kings College Hospital and Lewisham and Greenwich NHS Trusts, London, UK., Uzochukwu E; Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK., Tallantyre E; Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK.; Department of Clinical Neurology, University Hospital of Wales, Cardiff, UK., Wozniak E; Barts and the London Genome Centre, Queen Mary University of London, London, UK., Sacre E; Leeds Centre for Neurosciences, Leeds teaching Hospitals NHS Trust, Leeds, UK., Hassan-Smith G; University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK., Ford HL; Leeds Centre for Neurosciences, Leeds teaching Hospitals NHS Trust, Leeds, UK., Harris J; Northern Care Alliance NHS Trust, Manchester, UK., Bradley J; Hillingdon and Imperial NHS Trust, Uxbridge, UK., Breedon J; Preventive Neurology Unit, Wolfson Institute of Population Health, Queen Mary University of London, London, UK., Brooke J; Northern Care Alliance NHS Trust, Manchester, UK., Kreft KL; Department of Neurology, University Hospital of Wales, Cardiff, UK., Tuite Dalton K; Population Data Science, Swansea University Medical School, Swansea, UK., George K; Preventive Neurology Unit, Wolfson Institute of Population Health, Queen Mary University of London, London, UK., Papachatzaki M; Mid and South Essex NHS Foundation Trust, Southend-on-Sea, UK., O'Malley M; Leeds Centre for Neurosciences, Leeds teaching Hospitals NHS Trust, Leeds, UK., Peter M; Preventive Neurology Unit, Wolfson Institute of Population Health, Queen Mary University of London, London, UK., Mattoscio M; Department of neuroscience, Queen's Hospital, BHRUT NHS Trust, Romford, UK., Rhule N; Queen Elizabeth Hospital (Lewisham and Greenwich NHS Trust), London, UK., Evangelou N; Department of Neurology, Nottingham University Hospitals NHS Trust; Mental Health and Clinical Neuroscience Academic Unit, University of Nottingham School of Medicine, Nottingham, UK., Vinod N; Northern Care Alliance NHS Trust, Manchester, UK., Quinn O; Bradford Teaching Hospital Foundation Trust, Bradford, UK., Shamji R; Research and Innovation, Queen's Hospital, BHRUT, London, UK., Kaimal R; Preventive Neurology Unit, Wolfson Institute of Population Health, Queen Mary University of London, London, UK., Boulton R; Department of Neurology, Nottingham University Hospitals NHS Trust; Mental Health and Clinical Neuroscience Academic Unit, University of Nottingham School of Medicine, Nottingham, UK., Tanveer R; Lancashire Teaching Hospital NHS Foundation Trust, Preston, UK., Middleton R; Population Data Science, Swansea University Medical School, Swansea, UK., Murray R; Preventive Neurology Unit, Wolfson Institute of Population Health, Queen Mary University of London, London, UK., Bellfield R; Bradford Teaching Hospital Foundation Trust, Bradford, UK., Hoque S; Preventive Neurology Unit, Wolfson Institute of Population Health, Queen Mary University of London, London, UK., Patel S; Lancashire Teaching Hospital NHS Foundation Trust, Preston, UK., Raj S; Lancashire Teaching Hospital NHS Foundation Trust, Preston, UK., Gumus S; Mid and South Essex NHS Foundation Trust, Southend-on-Sea, UK., Mitchell S; Northern Care Alliance NHS Trust, Manchester, UK., Sawcer S; University of Cambridge, Department of Clinical Neuroscience, Addenbrookes Hospital, Hills Road, Cambridge, UK., Arun T; University Hospitals of Coventry and Warwickshire, Coventry, UK., Pogreban T; Research and Innovation, Queen's Hospital, BHRUT, London, UK., Brown TL; Preventive Neurology Unit, Wolfson Institute of Population Health, Queen Mary University of London, London, UK., Begum T; Preventive Neurology Unit, Wolfson Institute of Population Health, Queen Mary University of London, London, UK., Antoine V; Northern Care Alliance NHS Trust, Manchester, UK., Rashid W; St George's University Hospitals NHS Foundation Trust, London, UK., Noyce AJ; Preventive Neurology Unit, Wolfson Institute of Population Health, Queen Mary University of London, London, UK., Silber E; Kings College Hospital and Lewisham and Greenwich NHS Trusts, London, UK., Morris H; Department of Clinical and Movement Neuroscience, UCL Queen Square Institute of Neurology, London, UK., Giovannoni G; Preventive Neurology Unit, Wolfson Institute of Population Health, Queen Mary University of London, London, UK., Dobson R; Preventive Neurology Unit, Wolfson Institute of Population Health, Queen Mary University of London, London, UK ruth.dobson@qmul.ac.uk.
Jazyk:	angličtina
Zdroj:	BMJ open [BMJ Open] 2023 May 17; Vol. 13 (5), pp. e071656. Date of Electronic Publication: 2023 May 17.
DOI:	10.1136/bmjopen-2023-071656
Abstrakt:	Purpose: Genetic studies of multiple sclerosis (MS) susceptibility and severity have focused on populations of European ancestry. Studying MS genetics in other ancestral groups is necessary to determine the generalisability of these findings. The genetic Association study in individuals from Diverse Ancestral backgrounds with Multiple Sclerosis (ADAMS) project aims to gather genetic and phenotypic data on a large cohort of ancestrally-diverse individuals with MS living in the UK. Participants: Adults with self-reported MS from diverse ancestral backgrounds. Recruitment is via clinical sites, online (https://app.mantal.co.uk/adams) or the UK MS Register. We are collecting demographic and phenotypic data using a baseline questionnaire and subsequent healthcare record linkage. We are collecting DNA from participants using saliva kits (Oragene-600) and genotyping using the Illumina Global Screening Array V.3. Findings to Date: As of 3 January 2023, we have recruited 682 participants (n=446 online, n=55 via sites, n=181 via the UK MS Register). Of this initial cohort, 71.2% of participants are female, with a median age of 44.9 years at recruitment. Over 60% of the cohort are non-white British, with 23.5% identifying as Asian or Asian British, 16.2% as Black, African, Caribbean or Black British and 20.9% identifying as having mixed or other backgrounds. The median age at first symptom is 28 years, and median age at diagnosis is 32 years. 76.8% have relapsing-remitting MS, and 13.5% have secondary progressive MS. Future Plans: Recruitment will continue over the next 10 years. Genotyping and genetic data quality control are ongoing. Within the next 3 years, we aim to perform initial genetic analyses of susceptibility and severity with a view to replicating the findings from European-ancestry studies. In the long term, genetic data will be combined with other datasets to further cross-ancestry genetic discoveries. Competing Interests: Competing interests: None declared. (© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY. Published by BMJ.)
Databáze:	MEDLINE
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