Advances in malaria pharmacology and the online guide to MALARIA PHARMACOLOGY: IUPHAR review 38.

Autor: Armstrong JF; Deanery of Biomedical Sciences, The University of Edinburgh, Edinburgh, UK., Campo B; Medicines for Malaria Venture, Geneva, Switzerland., Alexander SPH; School of Life Sciences, University of Nottingham Medical School, Nottingham, UK., Arendse LB; Drug Discovery and Development Centre (H3D), South African Medical Research Council Drug Discovery and Development Research Unit, Department of Chemistry, and Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa., Cheng X; Global Health Drug Discovery Institute, Beijing, China., Davenport AP; Experimental Medicine and Immunotherapeutics, University of Cambridge, Cambridge, UK., Faccenda E; Deanery of Biomedical Sciences, The University of Edinburgh, Edinburgh, UK., Fidock DA; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, New York, USA.; Center for Malaria Therapeutics and Antimicrobial Resistance, Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, New York, USA., Godinez-Macias KP; Bioinformatics and Systems Biology Graduate Program, University of California, San Diego (UCSD), La Jolla, California, USA., Harding SD; Deanery of Biomedical Sciences, The University of Edinburgh, Edinburgh, UK., Kato N; Global Health Drug Discovery Institute, Beijing, China., Lee MCS; Parasites and Microbes Programme, Wellcome Sanger Institute, Hinxton, UK., Luth MR; Department of Pediatrics, University of California San Diego School of Medicine, La Jolla, California, USA., Mazitschek R; Center for Systems Biology, Massachusetts General Hospital, Boston, Massachusetts, USA., Mittal N; Thermo Fisher Scientific, San Diego, California, USA., Niles JC; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA., Okombo J; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, New York, USA., Ottilie S; Department of Pediatrics, University of California San Diego School of Medicine, La Jolla, California, USA., Pasaje CFA; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA., Probst AS; Department of Immunology and Infectious Diseases, Harvard TH Chan School of Public Health, Boston, Massachusetts, USA., Rawat M; Parasites and Microbes Programme, Wellcome Sanger Institute, Hinxton, UK., Rocamora F; Department of Pediatrics, University of California San Diego School of Medicine, La Jolla, California, USA., Sakata-Kato T; Global Health Drug Discovery Institute, Beijing, China., Southan C; Deanery of Biomedical Sciences, The University of Edinburgh, Edinburgh, UK., Spedding M; Spedding Research Solutions SAS, Le Vésinet, France., Tye MA; Center for Systems Biology, Massachusetts General Hospital, Boston, Massachusetts, USA., Yang T; Department of Pediatrics, School of Medicine, University of California, San Diego, La Jolla, California, USA., Zhao N; Global Health Drug Discovery Institute, Beijing, China., Davies JA; Deanery of Biomedical Sciences, The University of Edinburgh, Edinburgh, UK.
Jazyk: angličtina
Zdroj: British journal of pharmacology [Br J Pharmacol] 2023 Aug; Vol. 180 (15), pp. 1899-1929. Date of Electronic Publication: 2023 Jun 10.
DOI: 10.1111/bph.16144
Abstrakt: Antimalarial drug discovery has until recently been driven by high-throughput phenotypic cellular screening, allowing millions of compounds to be assayed and delivering clinical drug candidates. In this review, we will focus on target-based approaches, describing recent advances in our understanding of druggable targets in the malaria parasite. Targeting multiple stages of the Plasmodium lifecycle, rather than just the clinically symptomatic asexual blood stage, has become a requirement for new antimalarial medicines, and we link pharmacological data clearly to the parasite stages to which it applies. Finally, we highlight the IUPHAR/MMV Guide to MALARIA PHARMACOLOGY, a web resource developed for the malaria research community that provides open and optimized access to published data on malaria pharmacology.
(© 2023 The Authors. British Journal of Pharmacology published by John Wiley & Sons Ltd on behalf of British Pharmacological Society.)
Databáze: MEDLINE
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