Modular One-Pot Strategy for the Synthesis of Heterobivalent Tracers.
Autor: | Bailly T; Institut de Chimie Moléculaire de l'Université de Bourgogne, UMR CNRS 6302, Université de Bourgogne, 21000 Dijon, France., Bodin S; University of Bordeaux, CNRS, EPHE, INCIA, UMR 5287, Bordeaux F-33000, France., Goncalves V; Institut de Chimie Moléculaire de l'Université de Bourgogne, UMR CNRS 6302, Université de Bourgogne, 21000 Dijon, France., Denat F; Institut de Chimie Moléculaire de l'Université de Bourgogne, UMR CNRS 6302, Université de Bourgogne, 21000 Dijon, France., Morgat C; University of Bordeaux, CNRS, EPHE, INCIA, UMR 5287, Bordeaux F-33000, France.; Nuclear Medicine Department, University Hospital of Bordeaux, Bordeaux F-33000, France., Prignon A; UMS28 Laboratoire d'Imagerie Moléculaire Positonique (LIMP), Sorbonne Université, Paris 75020, France., Valverde IE; Institut de Chimie Moléculaire de l'Université de Bourgogne, UMR CNRS 6302, Université de Bourgogne, 21000 Dijon, France. |
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Jazyk: | angličtina |
Zdroj: | ACS medicinal chemistry letters [ACS Med Chem Lett] 2023 Apr 21; Vol. 14 (5), pp. 636-644. Date of Electronic Publication: 2023 Apr 21 (Print Publication: 2023). |
DOI: | 10.1021/acsmedchemlett.3c00057 |
Abstrakt: | Bivalent ligands, i.e., molecules having two ligands covalently connected by a linker, have been gathering attention since the first description of their pharmacological potential in the early 80s. However, their synthesis, particularly of labeled heterobivalent ligands, can still be cumbersome and time-consuming. We herein report a straightforward procedure for the modular synthesis of labeled heterobivalent ligands (HBLs) using dual reactive 3,6-dichloro-1,2,4,5-tetrazine as a starting material and suitable partners for sequential S Competing Interests: The authors declare no competing financial interest. (© 2023 American Chemical Society.) |
Databáze: | MEDLINE |
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