Cytotoxic effect of crotoxin on cancer cells and its antitumoral effects correlated to tumor microenvironment: A review.

Autor: Almeida TC; Laboratory of Pain and Signaling, Butantan Institute, 05503-900 São Paulo, Brazil. Electronic address: tamires.almeida.esib@esib.butantan.gov.br., Ribeiro Silva LM; Laboratory of Pain and Signaling, Butantan Institute, 05503-900 São Paulo, Brazil., Boaventura de Oliveira AM; Laboratory of Pain and Signaling, Butantan Institute, 05503-900 São Paulo, Brazil., Lopes FSR; Laboratory of Pain and Signaling, Butantan Institute, 05503-900 São Paulo, Brazil., Sant'Anna MB; Laboratory of Pain and Signaling, Butantan Institute, 05503-900 São Paulo, Brazil., Picolo G; Laboratory of Pain and Signaling, Butantan Institute, 05503-900 São Paulo, Brazil. Electronic address: gisele.picolo@butantan.gov.br.
Jazyk: angličtina
Zdroj: International journal of biological macromolecules [Int J Biol Macromol] 2023 Jul 01; Vol. 242 (Pt 2), pp. 124892. Date of Electronic Publication: 2023 May 15.
DOI: 10.1016/j.ijbiomac.2023.124892
Abstrakt: Cancer is the second leading cause of death worldwide, and despite the effort of standard treatments, the search for new tools against this disease is necessary. Importantly, it is known that the tumor microenvironment plays a crucial role in tumor initiation, progression, and response to therapies. Therefore, studies of potential drugs that act on these components are as critical as studies regarding antiproliferative substances. Through the years, studies of several natural products, including animal toxins, have been conducted to guide the development of medical compounds. In this review, we present the remarkable antitumor activities of crotoxin, a toxin from the rattlesnake Crotalus durissus terrificus, highlighting its effects on cancer cells and in the modulation of relevant elements in the tumor microenvironment as well as the clinical trials conducted with this compound. In summary, crotoxin acts through several mechanisms of action, such as activation of apoptosis, induction of cell cycle arrest, inhibition of metastasis, and decrease of tumor growth, in different tumor types. Crotoxin also modulates tumor-associated fibroblasts, endothelial cells, and immune cells, which contribute to its antitumoral effects. In addition, preliminary clinical studies confirm the promising results of crotoxin and support its potential future use as an anticancer drug.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023. Published by Elsevier B.V.)
Databáze: MEDLINE
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