Incidence of ventricular arrhythmias related to COVID infection and vaccination in patients with Brugada syndrome: Insights from a large Italian multicenter registry based on continuous rhythm monitoring.

Autor: Casella M; Cardiology and Arrhythmology Clinic, University Hospital Ospedali Riuniti Umberto I-Lancisi-Salesi, Ancona, Italy.; Department of Clinical, Special and Dental Sciences, Marche Polytechnic University, Ancona, Italy., Conti S; Department of Electrophysiology, ARNAS Civico - Di Cristina - Benfratelli, Palermo, Italy., Compagnucci P; Cardiology and Arrhythmology Clinic, University Hospital Ospedali Riuniti Umberto I-Lancisi-Salesi, Ancona, Italy.; Department of Biomedical Science and Public Health, Marche Polytechnic University, Ancona, Italy., Ribatti V; Centro Cardiologico Monzino IRCCS, Milan, Italy., Narducci ML; Fondazione Policlinico Universitario Agostino Gemelli, IRCCS, Rome, Italy., Marcon L; Centro Cardiologico Monzino IRCCS, Milan, Italy., Massara F; Cardiology and Arrhythmology Clinic, University Hospital Ospedali Riuniti Umberto I-Lancisi-Salesi, Ancona, Italy., Valeri Y; Cardiology and Arrhythmology Clinic, University Hospital Ospedali Riuniti Umberto I-Lancisi-Salesi, Ancona, Italy., De Francesco L; Fondazione Policlinico Universitario Agostino Gemelli, IRCCS, Rome, Italy., Martino AM; Department of Cardiology, Policlinico Casilino, Rome, Italy., Ghiglieno C; Division of Cardiology, University Hospital Maggiore della Carità, University of Eastern Piedmont, Novara, Italy., Schiavone M; Arrhythmology, Luigi Sacco Hospital, Milan, Italy., Balla C; Cardiovascular Institute, Azienda Ospedaliero-Universitaria di Ferrara, Cona, FE, Italy., Dell'Era G; Division of Cardiology, University Hospital Maggiore della Carità, University of Eastern Piedmont, Novara, Italy., Pelargonio G; Fondazione Policlinico Universitario Agostino Gemelli, IRCCS, Rome, Italy., Forleo GB; Arrhythmology, Luigi Sacco Hospital, Milan, Italy., Iacopino S; Maria Cecilia Hospital, GVM Care & Research, Cotignola, Italy., Sgarito G; Department of Electrophysiology, ARNAS Civico - Di Cristina - Benfratelli, Palermo, Italy., Calò L; Department of Cardiology, Policlinico Casilino, Rome, Italy., Tondo C; Centro Cardiologico Monzino IRCCS, Milan, Italy.; Department of Biomedical, Surgery and Dental Sciences, University of Milan, Milan, Italy., Russo AD; Cardiology and Arrhythmology Clinic, University Hospital Ospedali Riuniti Umberto I-Lancisi-Salesi, Ancona, Italy.; Department of Biomedical Science and Public Health, Marche Polytechnic University, Ancona, Italy., Patti G; Division of Cardiology, University Hospital Maggiore della Carità, University of Eastern Piedmont, Novara, Italy.
Jazyk: angličtina
Zdroj: Journal of cardiovascular electrophysiology [J Cardiovasc Electrophysiol] 2023 Jun; Vol. 34 (6), pp. 1386-1394. Date of Electronic Publication: 2023 May 17.
DOI: 10.1111/jce.15929
Abstrakt: Introduction: Brugada syndrome (BrS) has a dynamic ECG pattern that might be revealed by certain conditions such as fever. We evaluated the incidence and management of ventricular arrhythmias (VAs) related to COVID-19 infection and vaccination among BrS patients carriers of an implantable loop recorder (ILR) or implantable cardioverter-defibrillator (ICD) and followed by remote monitoring.
Methods: This was a multicenter retrospective study. Patients were carriers of devices with remote monitoring follow-up. We recorded VAs 6 months before COVID-19 infection or vaccination, during infection, at each vaccination, and up to 6-month post-COVID-19 or 1 month after the last vaccination. In ICD carriers, we documented any device intervention.
Results: We included 326 patients, 202 with an ICD and 124 with an ILR. One hundred and nine patients (33.4%) had COVID-19, 55% of whom developed fever. Hospitalization rate due to COVID-19 infection was 2.76%. After infection, we recorded only two ventricular tachycardias (VTs). After the first, second, and third vaccines, the incidence of non-sustained ventricular tachycardia (NSVT) was 1.5%, 2%, and 1%, respectively. The incidence of VT was 1% after the second dose. Six-month post-COVID-19 healing or 1 month after the last vaccine, we documented NSVT in 3.4%, VT in 0.5%, and ventricular fibrillation in 0.5% of patients. Overall, one patient received anti-tachycardia pacing and one a shock. ILR carriers had no VAs. No differences were found in VT before and after infection and before and after each vaccination.
Conclusions: From this large multicenter study conducted in BrS patients, followed by remote monitoring, the overall incidence of sustained VAs after COVID-19 infection and vaccination is relatively low.
(© 2023 Wiley Periodicals LLC.)
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje