Comparative impact of streptozotocin on altering normal glucose homeostasis in diabetic rats compared to normoglycemic rats.

Autor: Rehman HU; Department of Microbiology, University of Balochistan, Quetta, 87300, Pakistan., Ullah K; Department of Microbiology, University of Balochistan, Quetta, 87300, Pakistan. kaleemullah@um.uob.edu.pk., Rasool A; Institute of Biochemistry, University of Balochistan, Quetta, 87300, Pakistan., Manzoor R; Faculty of Marine Sciences, Water and Marine Sciences, Lasbella University of Agriculture, Uthal, 90150, Pakistan., Yuan Y; College of Life Sciences, North China University of Science and Technology, 21 Bo Hai Road, Tangshan, 063210, People's Republic of China., Tareen AM; Department of Microbiology, University of Balochistan, Quetta, 87300, Pakistan., Kaleem I; Department of Biosciences, COMSATS University Islamabad, Islamabad, Pakistan., Riaz N; Department of Biological Sciences, International Islamic University, Islamabad, Pakistan., Hameed S; National Institute of Genomics and Advanced Biotechnology (NIGAB) National Agriculture Research Council (NARC), Islamabad, Pakistan., Bashir S; Neurosciences Center, King Fahad Specialist Hospital Dammam, P.O. Box 15215, Dammam, Saudi Arabia. shahidbpk13@gmail.com.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2023 May 16; Vol. 13 (1), pp. 7921. Date of Electronic Publication: 2023 May 16.
DOI: 10.1038/s41598-023-29445-8
Abstrakt: Diabetes mellitus is a syndrome and an endocrine disorder, primarily considered as a loss of glucose homeostasis because of the insulin action and/or secretion or both. Currently there are more than 150 million people in the world affected by diabetes mellitus with a higher share of Asian and European countries. The current study aimed to investigate the comparative altering properties of streptozotocin (STZ), based on up-turn and down-turn configuration of biochemical, toxicological and hematological parameters in comparison with normoglycemic male albino rats. This comparative study was conducted among normoglycemic and STZ based induced-type 2 diabetic male albino rats groups. The male albino rats were intra-peritoneally injected with STZ with the dose rate of 65 mg/kg body weight for one time to developed type 2 diabetic model. Biochemical (blood glucose, uric acid, urea and creatinine), toxicological (AST, ALT and ALP) and hematological parameters (red and white blood cells) and their functional indices were evaluated in type 2 diabetic induced group along with normoglycemic rats. The STZ based induced- type 2 diabetic rats showed statistically significance (p < 0.001) higher level in the blood glucose, alongwith the change in the levels of biochemical parameters including urea, uric acid, and creatinine. Toxicological parameters comprising AST, ALT and ALP were also shown significance (p < 0.001) as sufficient after experimental evaluation of biologically important parameter in STZ based induced-type 2 diabetic rats. Likewise, the red blood cells, white blood cells and their efficient components were exposed significantly insufficient after the injecting of STZ to induce the rats as type 2 diabetic. The results of the current study indicates the comparatively higher levels of variation among biochemical, toxicological and hematological parameters in STZ based Induced-type 2 diabetic model as compared to normoglycemic group.
(© 2023. The Author(s).)
Databáze: MEDLINE
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