Investigating the effectiveness of electronically delivered cognitive behavioural therapy (e-CBTi) compared to pharmaceutical interventions in treating insomnia: Protocol for a randomized controlled trial.

Autor: Zhu Y; Faculty of Health Sciences, Queen's University, Kingston, Ontario, Canada., Stephenson C; Faculty of Health Sciences, Department of Psychiatry, Queen's University, Kingston, Ontario, Canada.; Faculty of Health Sciences, Centre for Neuroscience Studies, Queen's University, Kingston, Ontario, Canada., Moghimi E; Faculty of Health Sciences, Department of Psychiatry, Queen's University, Kingston, Ontario, Canada., Jagayat J; Faculty of Health Sciences, Department of Psychiatry, Queen's University, Kingston, Ontario, Canada.; Faculty of Health Sciences, Centre for Neuroscience Studies, Queen's University, Kingston, Ontario, Canada., Nikjoo N; Faculty of Health Sciences, Department of Psychiatry, Queen's University, Kingston, Ontario, Canada.; Faculty of Health Sciences, Centre for Neuroscience Studies, Queen's University, Kingston, Ontario, Canada., Kumar A; Faculty of Health Sciences, Department of Psychiatry, Queen's University, Kingston, Ontario, Canada., Shirazi A; Faculty of Health Sciences, Queen's University, Kingston, Ontario, Canada.; Faculty of Health Sciences, Department of Psychiatry, Queen's University, Kingston, Ontario, Canada.; Faculty of Health Sciences, Centre for Neuroscience Studies, Queen's University, Kingston, Ontario, Canada., Patel C; Faculty of Health Sciences, Department of Psychiatry, Queen's University, Kingston, Ontario, Canada., Omrani M; Faculty of Health Sciences, Department of Psychiatry, Queen's University, Kingston, Ontario, Canada.; OPTT Inc., Toronto, Ontario, Canada., Alavi N; Faculty of Health Sciences, Department of Psychiatry, Queen's University, Kingston, Ontario, Canada.; Faculty of Health Sciences, Centre for Neuroscience Studies, Queen's University, Kingston, Ontario, Canada.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2023 May 16; Vol. 18 (5), pp. e0285757. Date of Electronic Publication: 2023 May 16 (Print Publication: 2023).
DOI: 10.1371/journal.pone.0285757
Abstrakt: Background: Insomnia is one of the most prevalent sleep disorders characterized by an inability to fall or stay asleep. Available treatments include pharmacotherapy and cognitive behavioural therapy for insomnia (CBTi). Although CBTi is the first-line treatment, it has limited availability. Therapist-guided electronic delivery of CBT for insomnia (e-CBTi) offers scalable solutions to enhance access to CBTi. While e-CBTi produces comparable outcomes to in-person CBTi, there is a lack of comparison to active pharmacotherapies. Therefore, direct comparisons between e-CBTi and trazodone, one of the most frequently prescribed medications for insomnia, is essential in establishing the effectiveness of this novel digital therapy in the health care system.
Objective: The aim of this study is to compare the effectiveness of a therapist-guided electronically-delivered cognitive behavioural therapy (e-CBTi) program to trazodone in patients with insomnia.
Methods: Patients (n = 60) will be randomly assigned to two groups: treatment as usual (TAU) + trazodone and TAU + e-CBTi for seven weeks. Each weekly sleep module will be delivered through the Online Psychotherapy Tool (OPTT), a secure, online mental health care delivery platform. Changes in insomnia symptoms will be evaluated throughout the study using clinically validated symptomatology questionnaires, Fitbits, and other behavioural variables.
Results: Participant recruitment began in November 2021. To date, 18 participants have been recruited. Data collection is expected to conclude by December 2022 and analyses are expected to be completed by January 2023.
Conclusions: This comparative study will improve our understanding of the efficacy of therapist-guided e-CBTi in managing insomnia. These findings can be used to develop more accessible and effective treatment options and influence clinical practices for insomnia to further expand mental health care capacity in this population.
Trial Registration: ClinicalTrials.gov (NCT05125146).
Competing Interests: I have read the journal’s policy and the authors of this manuscript have the following competing interests: The principal investigator (NA) and collaborator (MO) have cofounded the care delivery platform in use (OPTT) and have ownership stakes in OPTT Inc., which is the platform used in the current study. Hence, NA and MO will not be involved in statistical analyses to mitigate potential conflicts of interest. The other authors have declared that no competing interests exist. This does not alter our adherence to PLOS ONE policies on sharing data and materials.
(Copyright: © 2023 Zhu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
Databáze: MEDLINE
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