| Autor: |
Deijle IA; Department of Neurology, OLVG Hospital, 1061 AE Amsterdam, The Netherlands.; Department of Quality and Improvement, OLVG Hospital, 1061 AE Amsterdam, The Netherlands., Van Wegen EEH; Department of Rehabilitation Medicine, Amsterdam UMC, Location Vrije Universiteit Amsterdam, Boelelaan 1117, 1081 HZ Amsterdam, The Netherlands.; Rehabilitation and Development, Amsterdam Movement Sciences, Amsterdam UMC, Location Vrije Universiteit Amsterdam, 1081 HZ Amsterdam, The Netherlands.; Amsterdam Neurosciences-Neurovascular Disorders, Amsterdam UMC, Location AMC, 1105 AZ Amsterdam, The Netherlands., Van den Berg-Vos RM; Department of Neurology, OLVG Hospital, 1061 AE Amsterdam, The Netherlands.; Amsterdam Neurosciences-Neurovascular Disorders, Amsterdam UMC, Location AMC, 1105 AZ Amsterdam, The Netherlands.; Department of Neurology, Amsterdam UMC, Location AMC, 1105 AZ Amsterdam, The Netherlands., Kwakkel G; Department of Rehabilitation Medicine, Amsterdam UMC, Location Vrije Universiteit Amsterdam, Boelelaan 1117, 1081 HZ Amsterdam, The Netherlands.; Rehabilitation and Development, Amsterdam Movement Sciences, Amsterdam UMC, Location Vrije Universiteit Amsterdam, 1081 HZ Amsterdam, The Netherlands.; Amsterdam Neurosciences-Neurovascular Disorders, Amsterdam UMC, Location AMC, 1105 AZ Amsterdam, The Netherlands.; Department of Physical Therapy and Human Movement Sciences, Northwestern University, Chicago, IL 60611, USA.; Department of Neurorehabilitation, Amsterdam Rehabilitation Research Centre, Reade, 1054 HW Amsterdam, The Netherlands. |
| Abstrakt: |
Fatigue is a common complaint and a disabling symptom among patients following transient ischemic attack (TIA) or minor stroke. In patients with stroke, decreased cardiorespiratory fitness (CRF) is believed to be related to increased severity of post-stroke fatigue (PSF). However, this association between PSF and CRF in patients with TIA or minor stroke has been less investigated, and currently there is no proven treatment for PSF. We aimed to determine the association between PSF and CRF in patients with TIA or minor stroke and to find out whether this association was distorted by confounders. A cross-sectional association study was conducted among a total of 119 patients with TIA or minor stroke. PSF was measured by the Fatigue Severity Scale (FSS) and CRF was quantified by maximal exercise capacity (V̇O2max). The FSS showed a significant association with V̇O2max (ß = -0.061, SE: 0.022; p = 0.007). This association was confounded by anxiety (ß = -0.044, SE: 0.020; p = 0.028) and depression (ß = -0.030, SE: 0.022; p = 0.177) as measured by the subscales of the Hospital Anxiety and Depression Scale (HADS). After controlling for HADS scores on depression and anxiety, the univariate relationship between V̇O2max and FSS was no longer significant. These results suggest that the association between PSF and CRF in patients with TIA or minor stroke is weak and significantly confounded by the factors of depression and anxiety. |
