Theranostics of Primary Prostate Cancer: Beyond PSMA and GRP-R.

Autor: Schollhammer R; Nuclear Medicine Department, Bordeaux University Hospital, 33000 Bordeaux, France.; INCIA, University of Bordeaux, CNRS, EPHE, UMR 5287, 33000 Bordeaux, France., Quintyn Ranty ML; Department of Pathology, University Hospital of Toulouse, 31000 Toulouse, France., de Clermont Gallerande H; Nuclear Medicine Department, Bordeaux University Hospital, 33000 Bordeaux, France.; INCIA, University of Bordeaux, CNRS, EPHE, UMR 5287, 33000 Bordeaux, France., Cavelier F; Institut des Biomolécules Max Mousseron IBMM, UMR 5247, CNRS, Université Montpellier, ENSCM, Pôle Chimie Balard, 1919 Route de Mende, Cedex 5, 34293 Montpellier, France., Valverde IE; Institut de Chimie Moléculaire de l'Université de Bourgogne, UMR 6302, CNRS, Université Bourgogne Franche-Comté, 9 Avenue Alain Savary, 21000 Dijon, France., Vimont D; INCIA, University of Bordeaux, CNRS, EPHE, UMR 5287, 33000 Bordeaux, France., Hindié E; Nuclear Medicine Department, Bordeaux University Hospital, 33000 Bordeaux, France.; INCIA, University of Bordeaux, CNRS, EPHE, UMR 5287, 33000 Bordeaux, France.; Institut Universitaire de France (IUF), 75231 Paris, France., Morgat C; Nuclear Medicine Department, Bordeaux University Hospital, 33000 Bordeaux, France.; INCIA, University of Bordeaux, CNRS, EPHE, UMR 5287, 33000 Bordeaux, France.
Jazyk: angličtina
Zdroj: Cancers [Cancers (Basel)] 2023 Apr 18; Vol. 15 (8). Date of Electronic Publication: 2023 Apr 18.
DOI: 10.3390/cancers15082345
Abstrakt: The imaging of Prostate-Specific Membrane Antigen (PSMA) is now widely used at the initial staging of prostate cancers in patients with a high metastatic risk. However, its ability to detect low-grade tumor lesions is not optimal.
Methods: First, we prospectively performed neurotensin receptor-1 (NTS 1 ) IHC in a series of patients receiving both [ 68 Ga]Ga-PSMA-617 and [ 68 Ga]Ga-RM2 before prostatectomy. In this series, PSMA and GRP-R IHC were also available (n = 16). Next, we aimed at confirming the PSMA/GRP-R/NTS 1 expression profile by retrospective autoradiography (n = 46) using a specific radiopharmaceuticals study and also aimed to decipher the expression of less-investigated targets such as NTS 2 , SST 2 and CXCR4.
Results: In the IHC study, all samples with negative PSMA staining (two patients with ISUP 2 and one with ISUP 3) were strongly positive for NTS 1 staining. No samples were negative for all three stains-for PSMA, GRP-R or NTS 1 . In the autoradiography study, binding of [ 111 In]In-PSMA-617 was high in all ISUP groups. However, some samples did not bind or bound weakly to [ 111 In]In-PSMA-617 (9%). In these cases, binding of [ 111 n]In-JMV 6659 and [ 111 In]In-JMV 7488 towards NTS 1 and NTS 2 was high.
Conclusions: Targeting PSMA and NTS 1 /NTS 2 could allow for the detection of all intraprostatic lesions.
Databáze: MEDLINE
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