Efficacy and Safety of [ 177 Lu]Lu-DOTA-TATE in Adults with Inoperable or Metastatic Somatostatin Receptor-Positive Pheochromocytomas/Paragangliomas, Bronchial and Unknown Origin Neuroendocrine Tumors, and Medullary Thyroid Carcinoma: A Systematic Literature Review.
| Autor: | Hertelendi M; Advanced Accelerator Applications International SA, 4 Rue de la Tour de l'Ile, 1204 Geneva, Switzerland., Belguenani O; Advanced Accelerator Applications International SA, 4 Rue de la Tour de l'Ile, 1204 Geneva, Switzerland., Cherfi A; Novartis Pharma AG, 4002 Basel, Switzerland., Folitar I; Novartis Pharma AG, 4002 Basel, Switzerland., Kollar G; Advanced Accelerator Applications International SA, 4 Rue de la Tour de l'Ile, 1204 Geneva, Switzerland., Polack BD; Novartis Pharmaceuticals, One Health Plaza, East Hanover, NJ 07936-1080, USA. |
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| Jazyk: | angličtina |
| Zdroj: | Biomedicines [Biomedicines] 2023 Mar 27; Vol. 11 (4). Date of Electronic Publication: 2023 Mar 27. |
| DOI: | 10.3390/biomedicines11041024 |
| Abstrakt: | Background: We have performed a systematic review to evaluate the efficacy and safety of [ 177 Lu]Lu-DOTA-TATE, a radioligand therapy, in advanced somatostatin receptor-positive pheochromocytoma/paraganglioma (PPGL), thymic neuroendocrine tumor (NET), bronchial NET, unknown primary NET, or medullary thyroid carcinoma (MTC). Methods: Studies identified in PubMed from inception to 13 May 2021 must have assessed [ 177 Lu]Lu-DOTA-TATE as a single agent and reported outcome data for the specific NET types of interest. Results: Two independent reviewers performed the screening and data extraction, resulting in 16 publications: PPGL ( n = 7), bronchial NETs ( n = 6; one also included NETs of unknown origin), and MTC ( n = 3). Overall, [ 177 Lu]Lu-DOTA-TATE offers encouraging antitumor activity (overall tumor response rates and disease control rates) across NET types. Safety was favorable with most adverse events mild to moderate in severity, transient, and consistent with those seen in patients with gastroenteropancreatic (GEP)-NETs. Conclusions: [ 177 Lu]Lu-DOTA-TATE has been used effectively in clinical practice to treat NETs of non-GEP origin. |
| Databáze: | MEDLINE |
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