The Promise of Precision Nutrition for Modulation of the Gut Microbiota as a Novel Therapeutic Approach to Acute Graft-versus-host Disease.
| Autor: | Lakshmanan AP; Translational Medicine Department, Research Branch, Sidra Medicine, Qatar., Deola S; Advanced Cell Therapy Core, Research Branch, Sidra Medicine, Qatar., Terranegra A; Translational Medicine Department, Research Branch, Sidra Medicine, Qatar. |
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| Jazyk: | angličtina |
| Zdroj: | Transplantation [Transplantation] 2023 Dec 01; Vol. 107 (12), pp. 2497-2509. Date of Electronic Publication: 2023 May 16. |
| DOI: | 10.1097/TP.0000000000004629 |
| Abstrakt: | Acute graft-versus-host disease (aGVHD) is a severe side effect of allogeneic hematopoietic stem cell transplantation (aHSCT) that has complex phenotypes and often unpredictable outcomes. The current management is not always able to prevent aGVHD. A neglected actor in the management of aGVHD is the gut microbiota. Gut microbiota dysbiosis after aHSCT is caused by many factors and may contribute to the development of aGVHD. Diet and nutritional status modify the gut microbiota and a wide range of products are now available to manipulate the gut microbiota (pro-, pre-, and postbiotics). New investigations are testing the effect of probiotics and nutritional supplements in both animal models and human studies, with encouraging results. In this review, we summarize the most recent literature about the probiotics and nutritional factors able to modulate the gut microbiota and we discuss the future perspective in developing new integrative therapeutic approaches to reducing the risk of graft-versus-host disease in patients undergoing aHSCT. Competing Interests: The authors declare no conflicts of interest. (Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc.) |
| Databáze: | MEDLINE |
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