Evaluation of circulating insulin-like growth factor-1, heart-type fatty acid-binding protein, and endotrophin levels as prognostic markers of COVID-19 infection severity.

Autor: Mohamed AA; Biochemistry and Molecular Biology Department, National Hepatology and Tropical Medicine Institute, Cairo, Egypt., Nour AA; Biochemistry and Molecular Biology Department, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt., Mosbah NM; Biochemistry and Molecular Biology Department, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt., Wahba ASM; Biochemistry and Molecular Biology Department, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt., Esmail OE; Biochemistry and Molecular Biology Department, Faculty of Pharmacy, Egyptian Russian University, Cairo, Egypt., Eysa B; Gastroenterology and Hepatology Department, National Hepatology and Tropical Medicine Institute, Cairo, Egypt., Heiba A; Internal Medicine Department, Medicine and Clinical Studies Research Institute, National Research Centre, Cairo, Egypt., Samir HH; Nephrology Unit, Internal Medicine Department, Faculty of Medicine, Cairo University, Cairo, Egypt., El-Kassas AA; Radiology Department, El-Sahel Teaching Hospital, Cairo, Egypt., Adroase AS; Clinical Pathology Department, El-Sahel Teaching Hospital, Cairo, Egypt., Elamir AY; Radiology Department, Faculty of Medicine, Cairo University, Cairo, Egypt., Mahmoud GM; Clinical Pathology Department, Faculty of Medicine, Benha University, Benha, Egypt., Rafaat RS; Neurology and Psychiatry Department, Faculty of Medicine, Minia University, Minia, Egypt., Hassan HA; Gastroenterology and Hepatology, Internal Medicine Department, Faculty of Medicine, Minia University, Minia, Egypt., El Abd YS; Microbial Biotechnology Department, Biotechnology Research Institute, National Research Centre, Cairo, Egypt. ys.el-abd@nrc.sci.eg.
Jazyk: angličtina
Zdroj: Virology journal [Virol J] 2023 May 15; Vol. 20 (1), pp. 94. Date of Electronic Publication: 2023 May 15.
DOI: 10.1186/s12985-023-02057-4
Abstrakt: Background: Coronavirus Disease 2019 (COVID-19) is a worldwide pandemic challenge spreading enormously within a few months. COVID-19 is characterized by the over-activation of the immune system causing cytokine storm. Insulin-like growth factor-1 (IGF-1) pathway can regulate the immune response via interaction with various implicated cytokines. Heart-type fatty acid-binding protein (H-FABP) has been shown to promote inflammation. Given the fact that coronavirus infections induce cytokines secretion leading to inflammatory lung injury, it has been suggested that H-FABP levels are affected by COVID-19 severity. Moreover, endotrophin (ETP), the cleavage product of collagen VI, may be an indicator of an overactive repair process and fibrosis, considering that viral infection may predispose or exacerbate existing respiratory conditions, including pulmonary fibrosis. This study aims to assess the prognostic capacity of circulating IGF-1, HFABP, and ETP, levels for COVID-19 severity progression in Egyptian patients.
Methods: The study cohort included 107 viral RNA-positive patients and an equivalent number of control individuals with no clinical signs of infection. Clinical assessments included profiling of CBC; serum iron; liver and kidney functions; inflammatory markers. Circulating levels of IGF-1; H-FABP, and ETP were estimated using the corresponding ELISA kits.
Results: No statistical difference in the body mass index was detected between the healthy and control groups, while the mean age of infected patients was significantly higher (P = 0.0162) than the control. Patients generally showed elevated levels of inflammatory markers including CRP and ESR concomitant with elevated serum ferritin; D dimer and procalcitonin levels, besides the COVID-19 characteristic lymphopenia and hypoxemia were also frequent. Logistic regression analysis revealed that oxygen saturation; serum IGF-1, and H-FABP can significantly predict the infection progression (P < 0.001 each). Both serum IGF-1 and H-FABP as well as O 2 saturation showed remarkable prognostic potentials in terms of large AUC values, high sensitivity/specificity values, and wide confidence interval. The calculated threshold for severity prognosis was 25.5 ng/mL; 19.5 ng/mL, 94.5, % and for IGF-1, H-FABP, and O 2 saturation; respectively. The calculated thresholds of serum IGF-1; H-FABP, and O 2 saturation showed positive and negative value ranges of 79-91% and 72-97%; respectively, with 66-95%, 83-94% sensitivity, and specificity; respectively.
Conclusion: The calculated cut-off values of serum IGF-1 and H-FABP represent a promising non-invasive prognostic tool that would facilitate the risk stratification in COVID-19 patients, and control the morbidity/mortality associated with progressive infection.
(© 2023. The Author(s).)
Databáze: MEDLINE
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