Maximizing the value of twin studies in health and behaviour.

Autor: Hagenbeek FA; Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands. f.a.hagenbeek@vu.nl.; Amsterdam Public Health Research Institute, Amsterdam, the Netherlands. f.a.hagenbeek@vu.nl., Hirzinger JS; Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.; Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands., Breunig S; Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.; Department of Psychology & Neuroscience, University of Colorado Boulder, Boulder, CO, USA.; Institute for Behavioral Genetics, University of Colorado Boulder, Boulder, CO, USA., Bruins S; Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.; Amsterdam Public Health Research Institute, Amsterdam, the Netherlands., Kuznetsov DV; Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.; Faculty of Sociology, Bielefeld University, Bielefeld, Germany., Schut K; Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.; Nightingale Health Plc, Helsinki, Finland., Odintsova VV; Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.; Amsterdam Reproduction & Development (AR&D) Research Institute, Amsterdam, the Netherlands.; Department of Psychiatry, University Medical Center of Groningen, University of Groningen, Groningen, the Netherlands., Boomsma DI; Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands. di.boomsma@vu.nl.; Amsterdam Public Health Research Institute, Amsterdam, the Netherlands. di.boomsma@vu.nl.; Amsterdam Reproduction & Development (AR&D) Research Institute, Amsterdam, the Netherlands. di.boomsma@vu.nl.
Jazyk: angličtina
Zdroj: Nature human behaviour [Nat Hum Behav] 2023 Jun; Vol. 7 (6), pp. 849-860. Date of Electronic Publication: 2023 May 15.
DOI: 10.1038/s41562-023-01609-6
Abstrakt: In the classical twin design, researchers compare trait resemblance in cohorts of identical and non-identical twins to understand how genetic and environmental factors correlate with resemblance in behaviour and other phenotypes. The twin design is also a valuable tool for studying causality, intergenerational transmission, and gene-environment correlation and interaction. Here we review recent developments in twin studies, recent results from twin studies of new phenotypes and recent insights into twinning. We ask whether the results of existing twin studies are representative of the general population and of global diversity, and we conclude that stronger efforts to increase representativeness are needed. We provide an updated overview of twin concordance and discordance for major diseases and mental disorders, which conveys a crucial message: genetic influences are not as deterministic as many believe. This has important implications for public understanding of genetic risk prediction tools, as the accuracy of genetic predictions can never exceed identical twin concordance rates.
(© 2023. Springer Nature Limited.)
Databáze: MEDLINE
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