Thrombocytopenia a predictor of malaria: how far?

Autor: Tiiba JI; Pharmacology Department, Faculty of Pharmaceutical Sciences, Ahmadu Bello University, Zaria, Nigeria., Ahmadu PU; Pharmacology and Toxicology Department, National Institute for Pharmaceutical Research and Development, Abuja, Nigeria., Naamawu A; Intensive Care Unit, Tamale Teaching Hospital, Tamale, Ghana., Fuseini M; Intensive Care Unit, Tamale Teaching Hospital, Tamale, Ghana., Raymond A; Laboratory Department, Tamale Teaching Hospital, Tamale, Ghana., Osei-Amoah E; Oncology Unit, Tamale Teaching Hospital, Tamale, Ghana., Bobrtaa PC; Department of Medicine, Tamale Teaching Hospital, Tamale, Ghana., Bacheyie PP; Laboratory Department, Tamale Teaching Hospital, Tamale, Ghana., Abdulai MA; Laboratory Department, Tamale Teaching Hospital, Tamale, Ghana., Alidu I; Laboratory Department, Tamale Teaching Hospital, Tamale, Ghana., Alhassan A; Laboratory Department, Tamale Teaching Hospital, Tamale, Ghana., Abdul Hamid JG; Laboratory Department, Tamale Teaching Hospital, Tamale, Ghana., Yussif A; Laboratory Department, Tamale Teaching Hospital, Tamale, Ghana., Tayawn PT; Laboratory Department, Tamale Teaching Hospital, Tamale, Ghana., Sakyi AA; Laboratory Department, Tamale Teaching Hospital, Tamale, Ghana., Yeng TN; Laboratory Department, Tamale Teaching Hospital, Tamale, Ghana., Aziz SA; Laboratory Department, Tamale Teaching Hospital, Tamale, Ghana., Mankana AH; Laboratory Department, Tamale Teaching Hospital, Tamale, Ghana., Husein WA; Laboratory Department, Tamale Teaching Hospital, Tamale, Ghana., Abdallah AW; Laboratory Department, Tamale Teaching Hospital, Tamale, Ghana., Mwininyaabu KS; Laboratory Department, Tamale Teaching Hospital, Tamale, Ghana., Kuffour MO; Laboratory Department, Tamale Teaching Hospital, Tamale, Ghana., Boateng EO; Laboratory Department, Tamale Teaching Hospital, Tamale, Ghana., Owusu-Achiaw B; Laboratory Department, Tamale Teaching Hospital, Tamale, Ghana., Eyulaku NJ; Laboratory Department, Tamale Teaching Hospital, Tamale, Ghana.
Jazyk: angličtina
Zdroj: Journal of parasitic diseases : official organ of the Indian Society for Parasitology [J Parasit Dis] 2023 Mar; Vol. 47 (1), pp. 1-11. Date of Electronic Publication: 2022 Dec 08.
DOI: 10.1007/s12639-022-01557-4
Abstrakt: Malaria is an acute febrile illness. It is a dangerous disease that contributes to millions of hospital visits and hundreds of thousands of deaths, especially in children residing in sub-Saharan Africa. In a non-immune individual, symptoms usually appear 10-15 days after the infective mosquito bite. The first symptoms-fever, headache, and chills-may be mild and difficult to recognize as malaria. If not treated within 24 h, P. falciparum malaria can progress to severe illness, often leading to death. Children with severe malaria frequently develop one or more of the following symptoms: severe anaemia, respiratory distress in relation to metabolic acidosis, or cerebral malaria. In adults, multi-organ involvement is also frequent. In malaria endemic areas, people may develop partial immunity, allowing asymptomatic infections to occur. Haematological changes are well-recognised with malarial infection however background haemoglobinopathy, nutritional status, demographic factors and malaria immunity play a major role in specific changes in that geographical region. Artemisinin derivatives are new generation antimalarial drugs they are used in the treatment of acute attacks of severe malaria including cerebral malaria. Information on the safety of these new antimalarial drugs on body function is still scanty. Haematological parameters are well studied in P. falciparum infection, but now recent studies have indicated that these changes do occur in P. vivax infection also. Hematological profile together with microscopy will enable rapid diagnosis, prompt treatment and further complications can be avoided. This current review is aimed at providing an up-to-date information on the role of malaria and anti-malarial drugs on haematological parameters especially thrombocytopenia.
Competing Interests: Conflict of interestThe authors declare that they have no conflict of interests.
(© Indian Society for Parasitology 2022, Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.)
Databáze: MEDLINE
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