Conductance-Based Phenomenological Nonspiking Model: A Dimensionless and Simple Model That Reliably Predicts the Effects of Conductance Variations on Nonspiking Neuronal Dynamics.

Autor: Naudin L; Laboratoire Lorrain de Recherche en Informatique et ses Applications, CNRS, Université de Lorraine, Nancy 5400, France lois.naudin@gmail.com., Raison-Aubry L; Laboratoire Lorrain de Recherche en Informatique et ses Applications, CNRS, Université de Lorraine, Nancy 5400, France laetitia.raison-aubry@loria.fr., Buhry L; Laboratoire Lorrain de Recherche en Informatique et ses Applications, CNRS, Université de Lorraine, Nancy 5400, France laure.buhry@loria.fr.
Jazyk: angličtina
Zdroj: Neural computation [Neural Comput] 2023 Jun 12; Vol. 35 (7), pp. 1209-1233.
DOI: 10.1162/neco_a_01589
Abstrakt: The modeling of single neurons has proven to be an indispensable tool in deciphering the mechanisms underlying neural dynamics and signal processing. In that sense, two types of single-neuron models are extensively used: the conductance-based models (CBMs) and the so-called phenomenological models, which are often opposed in their objectives and their use. Indeed, the first type aims to describe the biophysical properties of the neuron cell membrane that underlie the evolution of its potential, while the second one describes the macroscopic behavior of the neuron without taking into account all of its underlying physiological processes. Therefore, CBMs are often used to study "low-level" functions of neural systems, while phenomenological models are limited to the description of "high-level" functions. In this letter, we develop a numerical procedure to endow a dimensionless and simple phenomenological nonspiking model with the capability to describe the effect of conductance variations on nonspiking neuronal dynamics with high accuracy. The procedure allows determining a relationship between the dimensionless parameters of the phenomenological model and the maximal conductances of CBMs. In this way, the simple model combines the biological plausibility of CBMs with the high computational efficiency of phenomenological models, and thus may serve as a building block for studying both high-level and low-level functions of nonspiking neural networks. We also demonstrate this capability in an abstract neural network inspired by the retina and C. elegans networks, two important nonspiking nervous tissues.
(© 2023 Massachusetts Institute of Technology.)
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje