The Critical Role of the Adipocytokine NOV in Obstructive Sleep Apnea Induced Cardiometabolic Dysfunction: A Review.
| Autor: | Fakhouri EW; From the Department of Medicine, University of Missouri SOM, Columbia, MO., Peterson SJ; Department of Medicine, Weill Cornell Medicine, NY.; Department of Medicine, New York Presbyterian Brooklyn Methodist Hospital, Brooklyn, NY., Fakhouri W; Department of Biomedical Sciences, Northern Arizona University, Flagstaff, AZ., Minkin R; Department of Medicine, Weill Cornell Medicine, NY.; Department of Medicine, New York Presbyterian Brooklyn Methodist Hospital, Brooklyn, NY., Frishman WH; Department of Medicine, New York Medical College, Valhalla, NY., Weingarten JA; Department of Medicine, Weill Cornell Medicine, NY.; Department of Medicine, New York Presbyterian Brooklyn Methodist Hospital, Brooklyn, NY. |
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| Jazyk: | angličtina |
| Zdroj: | Cardiology in review [Cardiol Rev] 2024 Nov-Dec 01; Vol. 32 (6), pp. 554-557. Date of Electronic Publication: 2023 Apr 25. |
| DOI: | 10.1097/CRD.0000000000000556 |
| Abstrakt: | Obstructive sleep apnea (OSA) is highly prevalent and associated with oxidative stress, chronic inflammation, and adverse cardiovascular consequences. The comorbid condition of obesity remains epidemic. Both obesity and OSA are highly comorbid in patients with cardiovascular disease including atrial fibrillation, resistant hypertension, congestive heart failure, and coronary artery disease. Patients with these preexisting cardiovascular conditions should be screened for OSA with a low threshold to treat, even if OSA severity is mild. Nephroblastoma overexpressed (NOV/CCN3) protein has been identified in multiple chronic inflammatory states, most notably in obesity and more recently in OSA, even in the absence of obesity. As such, NOV may represent an important biomarker for oxidative stress in OSA and may lead to a deeper understanding of the relationship between OSA and its clinical sequelae. Competing Interests: Disclosure: The authors declare no conflict of interest. (Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc.) |
| Databáze: | MEDLINE |
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