Bone healing around implants placed in subjects with metabolically compromised systemic conditions.

Autor: Bergamo ETP; Biomaterials Division, NYU College of Dentistry, New York, New York, USA.; Department of Prosthodontics, University of Sao Paulo, School of Dentistry, Sao Paulo, Brazil., Witek L; Biomaterials Division, NYU College of Dentistry, New York, New York, USA.; Department of Biomedical Engineering, NYU Tandon School of Engineering, Brooklyn, New York, USA., Ramalho I; Department of Prosthodontics, University of Sao Paulo, School of Dentistry, Sao Paulo, Brazil., Lopes ACO; Department of Prosthodontics, University of Sao Paulo, School of Dentistry, Sao Paulo, Brazil., Nayak VV; Biomaterials Division, NYU College of Dentistry, New York, New York, USA.; Department of Mechanical and Aerospace Engineering, Tandon School of Engineering, Brooklyn, New York, USA., Bonfante EA; Department of Prosthodontics, University of Sao Paulo, School of Dentistry, Sao Paulo, Brazil., Tovar N; Biomaterials Division, NYU College of Dentistry, New York, New York, USA.; Department of Oral and Maxillofacial Surgery, NYU Langone Medical Center and Bellevue, Hospital Center, New York, New York, USA., Torroni A; Hansjörg Wyss Department of Plastic Surgery, Grossman School of Medicine, New York University, New York, New York, USA., Coelho PG; DeWitt Daughtry Family Department of Surgery, Division of Plastic Surgery, University of Miami Miller School of Medicine, Miami, Florida, USA.; Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, Miami, Florida, USA.
Jazyk: angličtina
Zdroj: Journal of biomedical materials research. Part B, Applied biomaterials [J Biomed Mater Res B Appl Biomater] 2023 Sep; Vol. 111 (9), pp. 1664-1671. Date of Electronic Publication: 2023 May 15.
DOI: 10.1002/jbm.b.35264
Abstrakt: The aim of this study was to evaluate the bone healing of tight-fit implants placed in the maxilla and mandible of subjects compromised with metabolic syndrome (MS) and type-2 Diabetes Mellitus (T2DM). Eighteen Göttingen minipigs were randomly distributed into three groups: (i) control (normal diet), (ii) MS (cafeteria diet for obesity induction), (iii) T2DM (cafeteria diet for obesity induction + Streptozotocin for T2DM induction). Maxillary and mandibular premolars and molar were extracted. After 8 weeks of healing, implants with progressive small buttress threads were placed, and allowed to integrate for 6 weeks after which the implant/bone blocks were retrieved for histological processing. Qualitative and quantitative histomorphometric analyses (percentage of bone-to-implant contact, %BIC, and bone area fraction occupancy within implant threads, %BAFO) were performed. The bone healing process around the implant occurred predominantly through interfacial remodeling with subsequent bone apposition. Data as a function of systemic condition yielded significantly higher %BIC and %BAFO values for healthy and MS relative to T2DM. Data as a function of maxilla and mandible did not yield significant differences for either %BIC and %BAFO. When considering both factors, healthy and MS subjects had %BIC and %BAFO trend towards higher values in the mandible relative to maxilla, whereas T2DM yielded higher %BIC and %BAFO in the maxilla relative to mandible. All systemic conditions presented comparable levels of %BIC and %BAFO in the maxilla; healthy and MS presented significantly higher %BIC and %BAFO relative to T2DM in the mandible. T2DM presented lower amounts of bone formation around implants relative to MS and healthy. Implants placed in the maxilla and in the mandible showed comparable amounts of bone in proximity to implants.
(© 2023 Wiley Periodicals LLC.)
Databáze: MEDLINE
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