Mood disturbance, but not overall diet quality, is associated with fecal microbiome diversity in free-living adults.

Autor: Smith KS; Department of Nutritional Sciences, Auburn University, Auburn, AL, USA., Morris MM; College of Science and Mathematics, Auburn University, Auburn, AL, USA., Morrow CD; Department of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL, USA., Novak JR; Department of Human Development and Family Science, Auburn University, Auburn, AL, USA., Roberts MD; School of Kinesiology, Auburn University, Auburn, AL, USA., Frugé AD; Department of Nutritional Sciences, Auburn University, Auburn, AL, USA.; College of Nursing, Auburn University, Auburn, AL, USA.
Jazyk: angličtina
Zdroj: Nutritional neuroscience [Nutr Neurosci] 2024 May; Vol. 27 (5), pp. 451-459. Date of Electronic Publication: 2023 May 15.
DOI: 10.1080/1028415X.2023.2213484
Abstrakt: Objectives: To investigate the gut-brain axis, we explored the relationships among mood disturbance (MD), diet quality (DQ), and fecal microbiota in free-living adults.
Methods: A cross-sectional analysis was conducted with data from 75 healthy adults enrolled in two studies. Anthropometrics, 16s rRNA gene sequencing of fecal microbes, DQ as assessed by Healthy Eating Index-2015 (HEI), and MD determined by Profile of Mood States (POMS) were included. Alpha-diversity and DQ differences were explored between low ( n  = 37) and high MD ( n  = 38) groups. Spearman correlations were used to investigate relationships between alpha-diversity, DQ, and POMS subscales. Moderation analysis explored the effect of HEI score on the relationship between MD and alpha-diversity.
Results: Participants were mostly white (67%), 54.5 years old (±11.8), and overweight (28.5 ± 6.5 kg/m 2 ). Shannon and Simpson indices indicate higher alpha-diversity in participants with low MD compared to high MD ( p  = 0.004 and p  = 0.008, respectively). Simpson and Shannon indices were correlated with subscale of anger (rho = -0.303, p  = 0.011; rho = -0.265, p  = 0.027, respectively)and total MD (rho = -0.404, p  = 0.001; rho = -0.357, p  = 0.002, respectively). Refined grains were associated with fatigue and tension subscales (rho = 0.428, p  <   0.001; rho = 0.302, p  = 0.014, respectively). DQ did not significantly moderate the relationship between alpha-diversity and mood disturbance ( F (7, 53) = 2.00, p  = 0.072, R 2  = 0.209). Shannon index was a significant predictor of MD ( b  = -4.39, t (53) = -2.55, p  = 0.014), but total HEI score and the interaction (Shannon index*HEI score) were not significant.
Discussion: Greater bacterial diversity was associated with lower MD, and DQ was associated with various mood state subscales in this sample of adults.
Databáze: MEDLINE
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