Boswellic Acids: A Critical Appraisal of Their Therapeutic and Nutritional Benefits in Chronic Inflammatory Diseases.

Autor:	Solanki N; Faculty of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, India., Gupta G; School of Pharmacy, Suresh Gyan Vihar University, Jaipur, India., Chellappan DK; Department of Life Sciences, School of Pharmacy, International Medical University, Bukit Jalil 57000, Kuala Lumpur, Malaysia., Singh SK; School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, 144411, India., Gulati M; School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, 144411, India., Paudel KR; Centre for Inflammation, Centenary Institute, Sydney 2050, Australia.; School of Life Sciences, Faculty of Science, University of Technology Sydney, 2007, Australia., Hansbro PM; Centre for Inflammation, Centenary Institute, Sydney 2050, Australia.; School of Life Sciences, Faculty of Science, University of Technology Sydney, 2007, Australia., Dua K; Centre for Inflammation, Centenary Institute, Sydney 2050, Australia.; Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, NSW, 2007, Australia.; Faculty of Health, Australian Research Centre in Complementary and Integrative Medicine, University of Technology Sydney, Ultimo, New South Wales, Australia., Bhan S; World College of Medical Science & Research, Jhajjar, India., Saini M; School of Medical and Allied Sciences, G.D. Goenka University, Gurugram, India., Dureja H; Faculty of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, India.
Jazyk:	angličtina
Zdroj:	Endocrine, metabolic & immune disorders drug targets [Endocr Metab Immune Disord Drug Targets] 2024; Vol. 24 (1), pp. 116-129.
DOI:	10.2174/1871530323666230512154634
Abstrakt:	Background: In the last few decades, it has been largely perceived that the factors affecting the immune system and its varying pathways lead to the pathological progression of inflammation and inflammatory conditions. Chronic inflammation also contributes to common diseases, such as diabetes mellitus, ischemic heart disease, cancer, chronic renal inflammatory disease, non-alcoholic fatty hepat-ic disease, autoimmune diseases and neurodegenerative diseases. Objective: Interestingly, plant sources and secondary metabolites from plants have been increasingly employed in managing acute and chronic inflammatory diseases for centuries. Boswellic acids are pentacyclic triterpenoidal moieties obtained from the oleo gum resin of different Boswellia species. Methods: Detailed data was collected revealing the anti-inflammatory potential of Boswellic acids through various databases. Result: These are pharmacologically active agents that possess promising anti-inflammatory, anti-arthritic, antirheumatic, anti-diarrheal, anti-hyperlipidemic, anti-asthmatic, anti-cancer, and anti-microbial effects. Conclusion: Boswellic acids have been in use since ancient times primarily to treat acute and chronic inflammatory diseases. This review discusses the various mechanisms underlying the inflammatory process and the necessity of such natural products as a medication to treat inflammatory diseases. In addition, a discussion has also been extended to understand the primary targets involved in inflammation. The review further explores the therapeutic potential of boswellic acids in. (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.)
Databáze:	MEDLINE
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