Sedative and cardiopulmonary effects of intranasal butorphanol with midazolam or dexmedetomidine in New Zealand white rabbits.

Autor: Okur S; Department of Surgery, Faculty of Veterinary Medicine, Atatürk University, Erzurum, Turkey., Yanmaz LE; Department of Surgery, Faculty of Veterinary Medicine, Burdur Mehmet Akif Ersoy University, Burdur, Turkey., Golgeli A; Department of Surgery, Faculty of Veterinary Medicine, Atatürk University, Erzurum, Turkey., Senocak MG; Department of Surgery, Faculty of Veterinary Medicine, Atatürk University, Erzurum, Turkey., Ersoz U; Department of Surgery, Faculty of Veterinary Medicine, Atatürk University, Erzurum, Turkey., Orhun OT; Department of Surgery, Faculty of Veterinary Medicine, Atatürk University, Erzurum, Turkey., Gumurcinler B; Department of Surgery, Faculty of Veterinary Medicine, Atatürk University, Erzurum, Turkey.
Jazyk: angličtina
Zdroj: The Veterinary record [Vet Rec] 2023 Jul 08; Vol. 193 (1), pp. e2999. Date of Electronic Publication: 2023 May 14.
DOI: 10.1002/vetr.2999
Abstrakt: Background: This study aimed to compare the sedative and cardiopulmonary effects of intranasal (IN) administration of dexmedetomidine-butorphanol (DB) and midazolam-butorphanol (MB) combinations in New Zealand white rabbits.
Methods: Eight New Zealand white rabbits were sedated by IN administration of a combination of 0.1 mg/kg dexmedetomidine and 0.4 mg/kg butorphanol (DB treatment) and 2 mg/kg midazolam and 0.4 mg/kg butorphanol (MB treatment). The electrocardiogram, pulse rate (PR), respiratory frequency (f R ), arterial haemoglobin oxygen saturation (SpO 2 ), fraction of expired carbon dioxide (EtCO 2 ), rectal temperature (RT), noninvasive mean arterial pressure (MAP), noninvasive systolic arterial pressure (SAP) and diastolic arterial pressure (DAP) were recorded. The onset of sedation, duration of sedation and sedation score (SS) were also noted.
Results: There were no significant differences in the EtCO 2 , RT, MAP, SAP and DAP measurements between treatments. The PR significantly decreased in DB compared with MB over time (p = 0.001). Compared with baseline, SpO 2 decreased over time in both treatments. The SS was significantly elevated over time in DB compared with MB (p = 0.002).
Limitations: No pharmacokinetic information was available for either treatment, so the findings should be interpreted cautiously.
Conclusions: IN DB provides more effective sedation than MB, but cardiopulmonary impairment was observed in both treatments.
(© 2023 The Authors. Veterinary Record published by John Wiley & Sons Ltd on behalf of British Veterinary Association.)
Databáze: MEDLINE
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