Sleep Deprivation in Middle Age May Increase Dementia Risk: A Review.
| Autor: | Balan I; Geriatrics, Montefiore Medical Center, Wakefield Campus, Bronx, USA., Bilger N; Clinical Simulation Center, Penn State University College of Medicine, Milton S. Hershey Medical Center, Hershey, USA., Saparov D; Internal Medicine, Brookdale University Hospital Medical Center, Brooklyn, USA., Hryb I; Neuroscience, University of Minnesota, Minneapolis, USA., Abdyraimov A; Biostatistics and Epidemiology, Ala-Too International University, Bishkek, KGZ. |
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| Jazyk: | angličtina |
| Zdroj: | Cureus [Cureus] 2023 Apr 11; Vol. 15 (4), pp. e37425. Date of Electronic Publication: 2023 Apr 11 (Print Publication: 2023). |
| DOI: | 10.7759/cureus.37425 |
| Abstrakt: | Neurodegenerative diseases present increasing interest in clinical practice for the aging population and involve dysregulation of sleep-wake behaviors. Approximately 5.8 million adults aged 65 and older were living with Alzheimer's disease (AD) in the United States in 2020 with increased mortality compared to the declining cardiovascular and cancer death rates. We conducted an extensive literature review to evaluate and synthesize evidence regarding the association between short sleep duration or sleep deprivation and the risk of developing all-cause dementia and Alzheimer's disease. There are multiple mechanisms describing brain damage, such as brain hypoxia, oxidative stress, or blood-brain barrier (BBB) impairment, induced by chronic sleep restriction (CSR) and the potential correlation with future cognitive decline and dementia. More studies are necessary to identify the specific factors involved in the sleep loss-cognitive decline association that could be taken into consideration while elaborating recommendations for dementia prevention measures. Competing Interests: The authors have declared that no competing interests exist. (Copyright © 2023, Balan et al.) |
| Databáze: | MEDLINE |
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