Dataset of RNA-Seq transcriptome of the fetal liver at day 83 of gestation associated with periconceptual maternal nutrition in beef heifers.

Autor:	Diniz WJS; Department of Animal Sciences, Auburn University, Auburn, AL 36849, United States., Ward AK; Department of Animal Sciences, and Center for Nutrition and Pregnancy, North Dakota State University, Fargo, ND 58108, United States., McCarthy KL; Department of Animal Science, University of Nebraska-Lincoln, Lincoln, NE 68583, United States., Kassetas CJ; Department of Animal Sciences, and Center for Nutrition and Pregnancy, North Dakota State University, Fargo, ND 58108, United States., Baumgaertner F; Department of Animal Sciences, and Center for Nutrition and Pregnancy, North Dakota State University, Fargo, ND 58108, United States., Reynolds LP; Department of Animal Sciences, and Center for Nutrition and Pregnancy, North Dakota State University, Fargo, ND 58108, United States., Borowicz PP; Department of Animal Sciences, and Center for Nutrition and Pregnancy, North Dakota State University, Fargo, ND 58108, United States., Sedivec KK; Central Grasslands Research and Extension Center, North Dakota State University, Streeter, ND 58483, United States., Kirsch JD; Department of Animal Sciences, and Center for Nutrition and Pregnancy, North Dakota State University, Fargo, ND 58108, United States., Dorsam ST; Department of Animal Sciences, and Center for Nutrition and Pregnancy, North Dakota State University, Fargo, ND 58108, United States., Neville TL; Department of Animal Sciences, and Center for Nutrition and Pregnancy, North Dakota State University, Fargo, ND 58108, United States., Forcherio JC; Purina Animal Nutrition LLC, Gray Summit, MO 63039, United States., Scott R; Purina Animal Nutrition LLC, Gray Summit, MO 63039, United States., Caton JS; Department of Animal Sciences, and Center for Nutrition and Pregnancy, North Dakota State University, Fargo, ND 58108, United States., Dahlen CR; Department of Animal Sciences, and Center for Nutrition and Pregnancy, North Dakota State University, Fargo, ND 58108, United States.
Jazyk:	angličtina
Zdroj:	Data in brief [Data Brief] 2023 Apr 23; Vol. 48, pp. 109173. Date of Electronic Publication: 2023 Apr 23 (Print Publication: 2023).
DOI:	10.1016/j.dib.2023.109173
Abstrakt:	Herein, we present a dataset based on the RNA-Seq analysis of liver tissue from bovine female fetuses at day 83 of gestation. The findings were reported in the main article, "Periconceptual maternal nutrition affects fetal liver programming of energy- and lipid-related genes" [1]. These data were generated to investigate the effects of periconceptual maternal vitamin and mineral supplementation and rates of body weight gain on the transcript abundance of genes associated with fetal hepatic metabolism and function. To this end, crossbred Angus beef heifers ( n  = 35) were randomly assigned to 1 of 4 treatments in a 2 × 2 factorial design. The main effects tested were vitamin and mineral supplementation (VTM or NoVTM - at least 71 days pre-breeding to day 83 of gestation) and rate of weight gain (low (LG - 0.28 kg/d) or moderate (MG - 0.79 kg/d) - from breeding to day 83). The fetal liver was collected on day 83 ± 0.27 of gestation. After total RNA isolation and quality control, strand-specific RNA libraries were prepared and sequenced on the Illumina® NovaSeq 6000 platform to generate paired-end 150-bp reads. After read mapping and counting, differential expression analysis was performed with edgeR. We identified 591 unique differentially expressed genes across all six vitamin-gain contrasts (FDR ≤ 0.1). To our knowledge, this is the first dataset investigating the fetal liver transcriptome in response to periconceptual maternal vitamin and mineral supplementation and/or the rate of weight gain. The data described in this article provides genes and molecular pathways differentially programming liver development and function. Competing Interests: Authors J. C. Forcherio and R. Scott are employees of Purina Animal Nutrition LLC (Land O'Lakes, Inc., Arden Hills, MN, USA), which sponsored the sample analysis for this experiment. Purina Animal Nutrition LLC manufactured the Purina® Wind & Rain® Storm® AllSeason 7.5 Complete mineral, the VTM and NoVTM pellets, and the protein/energy supplement used in this study. The funders had no role in the collection, analyses, or interpretation of data, in the writing of the manuscript, or in the decision to publish the results that were done entirely independently by North Dakota State University and Auburn University personnel. All the other authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (© 2023 The Author(s).)
Databáze:	MEDLINE
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