Developmental motor problems and health-related quality of life in 5-year-old children born extremely preterm: A European cohort study.

Autor: Aubert AM; Université Paris Cité, Inserm, INRAE, Centre for Research in Epidemiology and Statistics (CRESS), Obstetrical Perinatal and Pediatric Epidemiology Research Team, EPOPé, Paris, France., Costa R; EPIUnit, Instituto de Saúde Pública, Universidade do Porto, Porto, Portugal.; Laboratório para a Investigação Integrativa e Translacional em Saúde Populacional, Porto, Portugal., Johnson S; Department of Health Sciences, University of Leicester, Leicester, UK., Ådén U; Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.; Department of Bioclinical Sciences, Linköping University, Linköping, Sweden., Pierrat V; Université Paris Cité, Inserm, INRAE, Centre for Research in Epidemiology and Statistics (CRESS), Obstetrical Perinatal and Pediatric Epidemiology Research Team, EPOPé, Paris, France.; Department of Neonatology, Centre Hospitalier Intercommunal Créteil, Créteil, France., Cuttini M; Clinical Care and Management Innovation Research Area, Bambino Gesù Children's Hospital, Istituto di Ricovero e Cura a Carattere Scientifico, Rome, Italy., Männamaa M; Department of Paediatrics, Institute of Clinical Medicine, University of Tartu, Tartu, Estonia., Sarrechia I; Department of Medicine & Population Health, Faculty of Medicine & Health Sciences, University of Antwerp, Antwerp, Belgium., Lebeer J; Department of Neonatology, Sophia Children's Hospital and Erasmus University Medical Center, Rotterdam, the Netherlands., Van Heijst AF; Department of Neonatology, Sophia Children's Hospital and Erasmus University Medical Center, Rotterdam, the Netherlands., Maier RF; Children's Hospital, University Hospital, Philipps University Marburg, Marburg, Germany., Sentenac M; Université Paris Cité, Inserm, INRAE, Centre for Research in Epidemiology and Statistics (CRESS), Obstetrical Perinatal and Pediatric Epidemiology Research Team, EPOPé, Paris, France., Zeitlin J; Université Paris Cité, Inserm, INRAE, Centre for Research in Epidemiology and Statistics (CRESS), Obstetrical Perinatal and Pediatric Epidemiology Research Team, EPOPé, Paris, France.
Jazyk: angličtina
Zdroj: Developmental medicine and child neurology [Dev Med Child Neurol] 2023 Dec; Vol. 65 (12), pp. 1617-1628. Date of Electronic Publication: 2023 May 14.
DOI: 10.1111/dmcn.15632
Abstrakt: Aim: To measure the association between cerebral palsy (CP) and non-CP-related movement difficulties and health-related quality of life (HRQoL) among 5-year-old children born extremely preterm (<28 weeks gestational age).
Method: We included 5-year-old children from a multi-country, population-based cohort of children born extremely preterm in 2011 to 2012 in 11 European countries (n = 1021). Children without CP were classified using the Movement Assessment Battery for Children, Second Edition as having significant movement difficulties (≤5th centile of standardized norms) or being at risk of movement difficulties (6th-15th centile). Parents reported on a clinical CP diagnosis and HRQoL using the Pediatric Quality of Life Inventory. Associations were assessed using linear and quantile regressions.
Results: Compared to children without movement difficulties, children at risk of movement difficulties, with significant movement difficulties, and CP had lower adjusted HRQoL total scores (β [95% confidence interval] = -5.0 [-7.7 to -2.3], -9.1 [-12.0 to -6.1], and - 26.1 [-31.0 to -21.2]). Quantile regression analyses showed similar decreases in HRQoL for all children with CP, whereas for children with non-CP-related movement difficulties, reductions in HRQoL were more pronounced at lower centiles.
Interpretation: CP and non-CP-related movement difficulties were associated with lower HRQoL, even for children with less severe difficulties. Heterogeneous associations for non-CP-related movement difficulties raise questions for research about mitigating and protective factors.
(© 2023 The Authors. Developmental Medicine & Child Neurology published by John Wiley & Sons Ltd on behalf of Mac Keith Press.)
Databáze: MEDLINE
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