Production and therapeutic use of astaxanthin in the nanotechnology era.

Autor: Abdelazim K; Department of Biotechnology, Institute of Graduate Studies and Research, Alexandria University, Alexandria, Egypt., Ghit A; Department of Biotechnology, Institute of Graduate Studies and Research, Alexandria University, Alexandria, Egypt.; Department of Medicine and Aging Sciences, 'G. d'Annunzio' University of Chieti-Pescara, Chieti, Italy.; Center for Advanced Studies and Technology, 'G. d'Annunzio' University of Chieti-Pescara, Chieti, Italy., Assal D; Department of Biotechnology, Institute of Graduate Studies and Research, Alexandria University, Alexandria, Egypt.; Department of Biology, Biotechnology Program, American University in Cairo, Cairo, Egypt., Dorra N; Department of Microbiology and Immunology, Faculty of Pharmacy, Sinai University-Kantara Branch, Ismailia, Egypt., Noby N; Department of Biotechnology, Institute of Graduate Studies and Research, Alexandria University, Alexandria, Egypt., Khattab SN; Chemistry Department, Faculty of Science, Alexandria University, Alexandria, Egypt., El Feky SE; Radiation Sciences Department, Medical Research Institute, University of Alexandria, Alexandria, Egypt., Hussein A; Department of Biotechnology, Institute of Graduate Studies and Research, Alexandria University, Alexandria, Egypt. ahmed.hussein@alexu.edu.eg.
Jazyk: angličtina
Zdroj: Pharmacological reports : PR [Pharmacol Rep] 2023 Aug; Vol. 75 (4), pp. 771-790. Date of Electronic Publication: 2023 May 13.
DOI: 10.1007/s43440-023-00488-y
Abstrakt: Astaxanthin (AXT) is a red fat-soluble pigment found naturally in aquatic animals, plants, and various microorganisms and can be manufactured artificially using chemical catalysis. AXT is a xanthophyll carotenoid with a high potential for scavenging free radicals. Several studies have investigated AXT efficacy against diseases such as neurodegenerative, ocular, skin, and cardiovascular hypertension, diabetes, gastrointestinal and liver diseases, and immuno-protective functions. However, its poor solubility, low stability to light and oxygen, and limited bioavailability are major obstacles hindering its wide applications as a therapeutic agent or nutritional supplement. Incorporating AXT with nanocarriers holds great promise in enhancing its physiochemical properties. Nanocarriers are delivery systems with several benefits, including surface modification, bioactivity, and targeted medication delivery and release. Many approaches have been applied to enhance AXT's medicinal effect, including solid lipid nanoparticles, nanostructured lipid carriers (NLCs) and polymeric nanospheres. AXT nano-formulations have demonstrated a high antioxidant and anti-inflammatory effect, significantly affecting cancer in different organs. This review summarizes the most recent data on AXT production, characterization, biological activity, and therapeutic usage, focusing on its uses in the nanotechnology era.
(© 2023. The Author(s).)
Databáze: MEDLINE
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