Prenatal exposure to legacy PFAS and neurodevelopment in preschool-aged Canadian children: The MIREC cohort.

Autor: Goodman CV; Department of Psychology, York University, Toronto, ON, Canada., Till C; Department of Psychology, York University, Toronto, ON, Canada. Electronic address: Ctill@yorku.ca., Green R; Department of Psychology, York University, Toronto, ON, Canada., El-Sabbagh J; Department of Psychology, York University, Toronto, ON, Canada., Arbuckle TE; Environmental Health Science and Research Bureau, Health Canada, Ottawa, ON, Canada., Hornung R; Pediatrics and Environmental Health, Cincinnati Children's Hospital Medical Center (retired), United States., Lanphear B; Faculty of Health Sciences, Simon Fraser University, Burnaby, BC, Canada., Seguin JR; CHU Sainte-Justine Research Centre and Department of Psychiatry, School of Medicine, Université de Montréal, Montreal, QC, Canada., Booij L; CHU Sainte-Justine Research Centre and Department of Psychiatry, School of Medicine, Université de Montréal, Montreal, QC, Canada; Douglas Mental Health University Institute, Department of Psychiatry, McGill University, Montreal, QC, Canada., Fisher M; Environmental Health Science and Research Bureau, Health Canada, Ottawa, ON, Canada., Muckle G; École de psychologie, Université Laval, Centre de recherche du CHU de Québec-Université Laval, Montreal, QC, Canada., Bouchard MF; CHU Sainte-Justine Research Centre and Department of Environmental and Occupational Health, School of Public Health, Université de Montréal, Montreal, QC, Canada; Institut national de la recherche scientifique, Université du Quebec, Quebec City, QC, Canada., Ashley-Martin J; Environmental Health Science and Research Bureau, Health Canada, Ottawa, ON, Canada.
Jazyk: angličtina
Zdroj: Neurotoxicology and teratology [Neurotoxicol Teratol] 2023 Jul-Aug; Vol. 98, pp. 107181. Date of Electronic Publication: 2023 May 11.
DOI: 10.1016/j.ntt.2023.107181
Abstrakt: Background: Exposure to perfluoroalkyl substances (PFAS) has been shown to be neurotoxic in experimental studies, but epidemiological evidence linking prenatal PFAS exposure to child neurodevelopment is equivocal and scarce.
Objective: To quantify associations between prenatal exposure to legacy PFAS and children's intelligence (IQ) and executive functioning (EF) in a Canadian pregnancy and birth cohort and to determine if these associations differ by child sex.
Methods: We measured first-trimester plasma concentrations of perfluorooctanoic acid (PFOA), perfluorooctanesulfonic acid (PFOS), and perfluorohexanesulfonic acid (PFHxS) in the Maternal-Infant Research on Environmental Chemicals (MIREC) study and assessed children's full-scale (n = 522), performance (n = 517), and verbal (n = 519) IQ using the Wechsler Preschool and Primary Scale of Intelligence (WPPSI-III). Children's working memory (n = 513) and ability to plan and organize (n = 514) were assessed using a parent-reported questionnaire, the Behavior Rating Inventory of Executive Function - Preschool Version (BRIEF-P). We quantified associations between individual log2-transformed PFAS exposure and children's IQ and EF using multiple linear regression analyses and evaluated effect modification by child sex. We also used Repeated Holdout Weighted Quantile Sum (WQS) regression models with effect modification by child sex to quantify the effect of combined exposure to all three PFAS chemicals on IQ and EF. All models were adjusted for key sociodemographic characteristics.
Results: Geometric mean plasma concentrations (IQR) for PFOA, PFOS and PFHxS were 1.68 (1.10-2.50), 4.97 (3.20-6.20) and 1.09 (0.67-1.60) μg/L respectively. We found evidence of effect modification by child sex in all models examining performance IQ (p < .01). Specifically, every doubling of PFOA, PFOS, and or PFHxS was inversely associated with performance IQ, but only in males (PFOA: B = -2.80, 95% CI: -4.92, -0.68; PFOS: B = -2.64, 95% CI: -4.77, -0.52; PFHxS: B = -2.92, 95% CI: -4.72, -1.12). Similarly, every quartile increase in the WQS index was associated with poorer performance IQ in males (B = -3.16, 95% CI: -4.90, -1.43), with PFHxS contributing the largest weight to the index. In contrast, no significant association was found for females (B = 0.63, 95% CI: -0.99, 2.26). No significant associations were found for EF in either males or females.
Conclusions: Higher prenatal PFAS exposure was associated with lower performance IQ in males, suggesting that this association may be sex- and domain-specific.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Crown Copyright © 2023. Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: