Antibacterial Composite Material Based on Polyhydroxybutyrate and Zn-Doped Brushite Cement.

Autor: Fadeeva IV; A.A. Baikov Institute of Metallurgy and Material Science, Russian Academy of Sciences, Leninsky Prospect 49, 119334 Moscow, Russia., Deyneko DV; Chemistry Department, Lomonosov Moscow State University, Vorobievy Gory 1, 119991 Moscow, Russia.; Laboratory of Arctic Mineralogy and Material Sciences, Kola Science Centre, Russian Academy of Sciences, 14 Fersman Str., 184209 Apatity, Russia., Knotko AV; Chemistry Department, Lomonosov Moscow State University, Vorobievy Gory 1, 119991 Moscow, Russia., Olkhov AA; N.N. Semenov Federal Research Center for Chemical Physics, Russian Academy of Sciences, Kosygina Street 4, Building 1, 119991 Moscow, Russia.; Plekhanov Russian University of Economics, Stremyanny Lane 36, 117997 Moscow, Russia., Slukin PV; State Scientific Center of Applied Microbiology and Biotechnology of Rospotrebnadzor 24, Block A, 142279 Obolensk, Russia., Davydova GA; Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Institutskaya 3, 142290 Moscow, Russia., Trubitsyna TA; Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Institutskaya 3, 142290 Moscow, Russia., Preobrazhenskiy II; Materials Science Department, Lomonosov Moscow State University, Vorobievy Gory 1, 119991 Moscow, Russia., Gosteva AN; Kola Science Centre RAS, Tananaev Institute of Chemistry, Akademgorodok District 26A, 184209 Apatity, Russia., Antoniac IV; Faculty of Materials Science and Engineering, University Politehnica of Bucharest, 313 Splaiul Independentei Street, District 6, 060042 Bucharest, Romania.; Academy of Romanian Scientists, 54 Splaiul Independentei Street, District 5, 050094 Bucharest, Romania., Rau JV; Istituto di Struttura della Materia, Consiglio Nazionale delle Ricerche, ISM-CNR, Via del Fosso del Cavaliere 100, 00133 Rome, Italy.
Jazyk: angličtina
Zdroj: Polymers [Polymers (Basel)] 2023 Apr 28; Vol. 15 (9). Date of Electronic Publication: 2023 Apr 28.
DOI: 10.3390/polym15092106
Abstrakt: A composite material based on electrospinning printed polyhydroxybutyrate fibers impregnated with brushite cement containing Zn substitution was developed for bone implant applications. Powder X-ray Diffraction (PXRD), Fourier Transform Infrared Spectroscopy and Scanning Electron Microscopy were applied for materials characterization. Soaking the composite in Ringer's solution led to the transformation of brushite into apatite phase, accompanied by the morphology changes of the material. The bending strength of the composite material was measured to be 3.1 ± 0.5 MPa. NCTC mouse fibroblast cells were used to demonstrate by means of the MTT test that the developed material was not cytotoxic. The behavior of the human dental pulp stem cells on the surface of the composite material investigated by the direct contact method was similar to the control. It was found that the developed Zn containing composite material possessed antibacterial properties, as testified by microbiology investigations against bacteria strains of Escherichia coli and Staphylococcus aureus . Thus, the developed composite material is promising for the treatment of damaged tissues with bacterial infection complications.
Databáze: MEDLINE
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