Biodegradable Polycaprolactone Fibers with Silica Aerogel and Nanosilver Particles Produce a Coagulation Effect.

Autor: Ayvazoğlu BŞ; Institute of Forensic Sciences, Turkish National Police Academy, 06834 Ankara, Turkey., Ceylan M; Graduate School of Natural and Applied Sciences, Istanbul Ticaret University, 34840 Istanbul, Turkey., Turan AAI; Institute of Forensic Sciences, Turkish National Police Academy, 06834 Ankara, Turkey., Yılmaz EB; Graduate School of Natural and Applied Sciences, Istanbul Ticaret University, 34840 Istanbul, Turkey.
Jazyk: angličtina
Zdroj: Polymers [Polymers (Basel)] 2023 Apr 24; Vol. 15 (9). Date of Electronic Publication: 2023 Apr 24.
DOI: 10.3390/polym15092022
Abstrakt: Poly-ε-caprolactone (PCL) is a biodegradable aliphatic polyester that can be used in the field of biomaterials. Electrospinning is the name given to the process of producing micro and nanoscale fibers using electrostatically charged polymeric solutions under certain conditions. Almost all synthetic and naturally occurring polymers can undergo electrospinning using suitable solvents or mixtures prepared in certain proportions. In this study, silica aerogels were obtained by the sol-gel method. PCL-silica aerogel fibers were synthesized by adding 0.5, 1, 2, and 4% ratios in the PCL solution. Blood contact analysis was performed on the produced fibers with UV-VIS. According to the results obtained, 0.5, 1, 2, and 4% nano-silver were added to the fiber-containing 4% aerogel. Then, SEM-EDS and FTIR analyses were performed on all fibers produced. Antimicrobial tests were performed on fibers containing nano-silver. As a result, high-performance blood coagulation fibers were developed using PCL with aerogel, and an antimicrobial effect was achieved with nano-silver particles. It is thought that the designed surface will be preferred in wound dressing and biomaterial in tissue engineering, as it provides a high amount of cell adhesion with a small amount of blood and contains antimicrobial properties.
Databáze: MEDLINE
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