| Autor: |
Golubeva OY; Laboratory of Silicate Sorbents Chemistry, Institute of Silicate Chemistry of Russian Academy of Sciences, Adm. Makarova emb., 2, 199034 St. Petersburg, Russia., Alikina YA; Laboratory of Silicate Sorbents Chemistry, Institute of Silicate Chemistry of Russian Academy of Sciences, Adm. Makarova emb., 2, 199034 St. Petersburg, Russia., Brazovskaya EY; Laboratory of Silicate Sorbents Chemistry, Institute of Silicate Chemistry of Russian Academy of Sciences, Adm. Makarova emb., 2, 199034 St. Petersburg, Russia., Vasilenko NM; Laboratory of Silicate Sorbents Chemistry, Institute of Silicate Chemistry of Russian Academy of Sciences, Adm. Makarova emb., 2, 199034 St. Petersburg, Russia. |
| Abstrakt: |
The factors influencing the appearance of toxicity in samples of synthetic montmorillonite with a systematically changing chemical composition Na x (Al, Mg) 2-3 Si 4 O 10 (OH) 2 nH 2 O, which are potentially important for their use in medicine as drug carriers, targeted drug delivery systems, entero- and hemosorbents have been studied. Samples synthesized under hydrothermal conditions had the morphology of nanolayers self-organized into the nanosponge structures. The effect of the aluminum content, particle sizes, porosity, and ζ-potential of the samples on their toxicity was studied. The cytotoxic effect of the samples on eukaryotic cells Ea. hy 926 was determined using the MTT assay. The hemolytic activity of the samples in the wide concentration range in relation to human erythrocytes was also estimated. It has been established that the toxicity of aluminosilicate nanoparticles can be significantly reduced by correctly selecting their synthesis conditions and chemical composition, which opens up the opportunities for their use in medicine. |
