Impact of Single Hemodialysis Treatment on immune Cell Subpopulations.

Autor: Donadei C; Nephrology, Dialysis and Renal Transplant Unit, IRCCS-Azienda Ospedaliero-Universitaria di Bologna, 40139 Bologna, Italy., Angeletti A; Division of Nephrology, Dialysis and Transplantation, IRCCS Istituto Giannina Gaslini, Genoa Largo Gaslini, 16148 Genoa, Italy., Pizzuti V; Department of Medical and Surgical Sciences (DIMEC), University of Bologna, 40126 Bologna, Italy., Zappulo F; Nephrology, Dialysis and Renal Transplant Unit, IRCCS-Azienda Ospedaliero-Universitaria di Bologna, 40139 Bologna, Italy., Conte D; Department of Medical and Surgical Sciences (DIMEC), University of Bologna, 40126 Bologna, Italy., Cappuccilli M; Department of Medical and Surgical Sciences (DIMEC), University of Bologna, 40126 Bologna, Italy., Chiocchini AL; Nephrology, Dialysis and Renal Transplant Unit, IRCCS-Azienda Ospedaliero-Universitaria di Bologna, 40139 Bologna, Italy., Scrivo A; Nephrology, Dialysis and Renal Transplant Unit, IRCCS-Azienda Ospedaliero-Universitaria di Bologna, 40139 Bologna, Italy., Apuzzo D; Nephrology, Dialysis and Renal Transplant Unit, IRCCS-Azienda Ospedaliero-Universitaria di Bologna, 40139 Bologna, Italy., Mariggiò MA; Department of Precision and Regenerative Medicine and Area Jonica, School of Medicine, University of Bari, 70121 Bari, Italy., Gasperoni L; Nephrology, Dialysis and Renal Transplant Unit, IRCCS-Azienda Ospedaliero-Universitaria di Bologna, 40139 Bologna, Italy.; Nephrology and Dialysis Unit, Infermi Hospital, AUSL Romagna, 47923 Rimini, Italy., Donati G; Nephrology, Dialysis and Renal Transplant Unit, Azienda Ospedaliero Universitaria di Modena, 41124 Modena, Italy.; Surgical, Medical, Dental and Morphological Sciences Department (CHIMOMO), University of Modena and Reggio Emilia, 41124 Modena, Italy., La Manna G; Nephrology, Dialysis and Renal Transplant Unit, IRCCS-Azienda Ospedaliero-Universitaria di Bologna, 40139 Bologna, Italy.; Department of Medical and Surgical Sciences (DIMEC), University of Bologna, 40126 Bologna, Italy.
Jazyk: angličtina
Zdroj: Journal of clinical medicine [J Clin Med] 2023 Apr 25; Vol. 12 (9). Date of Electronic Publication: 2023 Apr 25.
DOI: 10.3390/jcm12093107
Abstrakt: Hemodialysis (HD) is known to trigger a chronic inflammatory status, affecting the innate and acquired immune response. This study was aimed at a comparative analysis of immune cell subsets, proliferation, and apoptosis in subjects receiving chronic HD treatment with respect to a healthy control. Regardless of the dialysis filter used, we observed a reshaping of the acquired immune component both with respect to healthy patients and between the various sessions of dialysis treatment, with an impairment of CD3 cells, along with an increase in CD4 and CD8 cell populations producing pro-inflammatory factors such as IL-17 and IFN-gamma. The population of B cells, monocytes and NK cells were not impaired by the dialysis procedure. These results confirmed the high impact of the HD treatment on the patient's immune system, underlying the imbalance of T cell counterparts.
Databáze: MEDLINE
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