| Autor: |
Keidel LF; Department of Ophthalmology, Ludwig-Maximilians-University, 80336 Munich, Germany., Schworm B; Department of Ophthalmology, Ludwig-Maximilians-University, 80336 Munich, Germany., Langer J; Department of Ophthalmology, Ludwig-Maximilians-University, 80336 Munich, Germany., Luft N; Department of Ophthalmology, Ludwig-Maximilians-University, 80336 Munich, Germany., Herold T; Department of Ophthalmology, Ludwig-Maximilians-University, 80336 Munich, Germany., Hagenau F; Department of Ophthalmology, Ludwig-Maximilians-University, 80336 Munich, Germany., Klaas JE; Department of Ophthalmology, Ludwig-Maximilians-University, 80336 Munich, Germany., Priglinger SG; Department of Ophthalmology, Ludwig-Maximilians-University, 80336 Munich, Germany., Siedlecki J; Department of Ophthalmology, Ludwig-Maximilians-University, 80336 Munich, Germany. |
| Abstrakt: |
In the pathophysiology of central serous chorioretinopathy (CSC), scleral changes inducing increased venous outflow resistance are hypothesized to be involved. This work aims to investigate anterior scleral thickness (AST) as a risk factor for pachychoroid disorders. A randomized prospective case-control study was performed at the Ludwig Maximilians University, Department of Ophthalmology. In patients with CSC or pachychoroid neovasculopathy (PNV) and in an age- and refraction-matched control group, swept source optical coherence tomography (SS-OCT) was used to measure anterior scleral thickness (AST). Subfoveal choroidal thickness (SFCT) was assessed using enhanced depth imaging OCT (EDI-OCT). In total, 46 eyes of 46 patients were included in this study, with 23 eyes in the CSC/PNV and 23 eyes in the control group. A significantly higher AST was found in the CSC/PNV compared with the control group (403.5 ± 68.6 (278 to 619) vs. 362.5 ± 62.6 (218 to 498) µm; p = 0.028). Moreover, the CSC/PNV group showed a higher SFCT (392.8 ± 92.8 (191-523) vs. 330.95 ± 116.5 (167-609) µm, p = 0.004). Compared with the age- and refraction-matched controls, patients with CSC and PNV showed a significantly thicker anterior sclera. Scleral thickness might contribute to the venous overload hypothesized to induce pachychoroid phenotypes. |
