Dietary Choline and Betaine Intake and Risk of Colorectal Cancer in an Iranian Population.

Autor: Seyyedsalehi MS; Department of Medical and Surgical Sciences, University of Bologna, 40138 Bologna, Italy.; Cancer Research Center, Cancer Institute, Tehran University of Medical Sciences, Tehran 5166614711, Iran., Rossi M; The Department of Clinical Sciences and Community Health, Università Degli Studi di Milano, 20133 Milan, Italy., Hadji M; Cancer Research Center, Cancer Institute, Tehran University of Medical Sciences, Tehran 5166614711, Iran.; Health Sciences Unit, Faculty of Social Sciences, Tampere University, 33521 Tampere, Finland., Rashidian H; Cancer Research Center, Cancer Institute, Tehran University of Medical Sciences, Tehran 5166614711, Iran., Marzban M; Department of Human Genetics, McGill University, Montreal, QC 3640, Canada., Parpinel M; Department of Medicine, University of Udine, Via Colugna 50, 33100 Udine, Italy., Fiori F; Department of Medicine, University of Udine, Via Colugna 50, 33100 Udine, Italy., Naghibzadeh-Tahami A; Modeling in Health Research Center, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman 7619833477, Iran.; Health Foresight and Innovation Research Center, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman 7619833477, Iran., Hannun YA; Stony Brook Cancer Center, Stony Brook University, New York, NY 11794, USA.; Department of Medicine, Stony Brook University, New York, NY 11794, USA., Luberto C; Stony Brook Cancer Center, Stony Brook University, New York, NY 11794, USA.; Department of Physiology and Biophysics, Stony Brook University, Stony Brook, NY 11794, USA., Zendehdel K; Cancer Research Center, Cancer Institute, Tehran University of Medical Sciences, Tehran 5166614711, Iran.; Cancer Biology Research Center, Cancer Institute, Tehran University of Medical Sciences, Tehran 5166614711, Iran., Boffetta P; Department of Medical and Surgical Sciences, University of Bologna, 40138 Bologna, Italy.; Stony Brook Cancer Center, Stony Brook University, New York, NY 11794, USA.
Jazyk: angličtina
Zdroj: Cancers [Cancers (Basel)] 2023 Apr 29; Vol. 15 (9). Date of Electronic Publication: 2023 Apr 29.
DOI: 10.3390/cancers15092557
Abstrakt: Background: Colorectal cancer (CRC) is increasing in low- and middle-income countries, likely due to changing lifestyle habits, including diet. We aimed to investigate the relationship between dietary betaine, choline, and choline-containing compounds and CRC risk.
Methods: We analyzed data from a case-control study, including 865 CRC cases and 3206 controls from Iran. Detailed information was collected by trained interviewers using validated questionnaires. The intake of free choline, phosphocholine (Pcho), glycerophosphocholine (GPC), phosphatidylcholine (PtdCho), and sphingomyelin (SM), as well as of betaine was estimated from food frequency questionnaires and categorized into quartiles. The odds ratios (OR) and 95% confidence intervals (CI) of CRC for choline and betaine quartiles were calculated using multivariate logistic regression by adjusting for potential confounders.
Results: We observed excess risk of CRC in the highest versus lowest intake of total choline (OR = 1.23, 95% CI 1.13, 1.33), GPC (OR = 1.13, 95% CI 1.00, 1.27), and SM (OR = 1.14, 95% CI 1.01, 1.28). The intake of betaine exerted an inverse association with CRC risk (OR = 0.91, 95% CI 0.83, 0.99). There was no association between free choline, Pcho, PtdCho, and CRC. Analyses stratified by gender showed an elevated OR of CRC in men for SM intake OR = 1.20, 95% CI 1.03, 1.40) and a significantly decreased CRC risk in women for betaine intake (OR = 0.84, 95% CI 0.73, 0.97).
Conclusion: Dietary modifications leading to an increase in betaine sources and managing the use of animal products as references for SM or other choline types might contribute to decreasing the risk of CRC.
Databáze: MEDLINE
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