A rare complication of leukostasis with AML M4 patient: Microcirculatory dysfunction of upper extremities.

Autor: Ersayoğlu İ; Ege University Medical School, Children's Hospital Pediatric Intensive Care Unit, İzmir, Turkey. Electronic address: irem_e@hotmail.com., Yazıcı Özkaya P; Ege University Medical School, Children's Hospital Pediatric Intensive Care Unit, İzmir, Turkey. Electronic address: dryazicipinar@gmail.com., Metin H; Ege University Medical School, Children's Hospital Pediatric Intensive Care Unit, İzmir, Turkey. Electronic address: hamdimetin919@hotmail.com., Hekimci H; Ege University Medical School, Children's Hospital Pediatric Hematology, İzmir, Turkey. Electronic address: hamiyethekimci@hotmail.com., Zararcı K; Ege University Medical School, Children's Hospital Pediatric Intensive Care Unit, İzmir, Turkey. Electronic address: zonguldak6735@hotmail.com., Yılmaz Karapınar D; Ege University Medical School, Children's Hospital Pediatric Hematology, İzmir, Turkey. Electronic address: dyilmazk@yahoo.com., Karapınar B; Ege University Medical School, Children's Hospital Pediatric Intensive Care Unit, İzmir, Turkey. Electronic address: bkarapinar@hotmail.com.
Jazyk: angličtina
Zdroj: Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis [Transfus Apher Sci] 2023 Aug; Vol. 62 (4), pp. 103717. Date of Electronic Publication: 2023 May 02.
DOI: 10.1016/j.transci.2023.103717
Abstrakt: Background: In children with acute myeloid leukemia, the incidence of hyperleukocytosis is 5-33%. Patients with AML and hyperleukocytosis have a higher early mortality rate than patients with nonhyperleukocytic AML because of the increased risk of severe pulmonary and neurologic complications. Leukapheresis provides rapid cytoreduction and reduces early mortality rates.
Case Presentation: In this report, we present a case with microcirculatory failure of upper extremities as a rare symptom of hyperleukocytic AML M4 at initial presentation.
Conclusions: Early diagnosis and treatment of patients with AML admitted to emergency services with these symptoms is too important to prevent from loss of extremities. Most of the complications of hyperleukocytosis can be reversible with early treatment.
(Copyright © 2023 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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