A review and meta-analysis: Cross-tissue telomere length correlations in healthy humans.

Autor: McLester-Davis LWY; Tulane University Tulane Brain Institute, United States., Estrada P; Princeton University Graduate School Neuroscience Institute, United States. Electronic address: pestrada@tulane.edu., Hastings WJ; Tulane University School of Medicine, United States. Electronic address: whastings1@tulane.edu., Kataria LA; Louisiana State University School of Medicine, United States. Electronic address: lkataria@tulane.edu., Martin NA; Tulane University School of Science and Engineering, United States. Electronic address: nmartin9@tulane.edu., Siebeneicher JT; Tulane University School of Science and Engineering, United States. Electronic address: jsiebeneicher@tulane.edu., Tristano RI; University of Chicago Pritzker School of Medicine, United States. Electronic address: renee.tristano@uchicagomedicine.org., Mayne CV; Tulane University School of Medicine, United States. Electronic address: cmayne@tulane.edu., Horlick RP; Tulane University Libraries, United States. Electronic address: rhorlick@tulane.edu., O'Connell SS; Louisiana State University School of Medicine, United States; Tulane University School of Public Health and Tropical Medicine, United States. Electronic address: soconne1@tulane.edu., Drury SS; Tulane University School of Medicine, United States. Electronic address: sdrury@tulane.edu.
Jazyk: angličtina
Zdroj: Ageing research reviews [Ageing Res Rev] 2023 Jul; Vol. 88, pp. 101942. Date of Electronic Publication: 2023 May 10.
DOI: 10.1016/j.arr.2023.101942
Abstrakt: Background and Aim: Tissue source has been shown to exert a significant effect on the magnitude of associations between telomere length and various health outcomes and exposures. The purpose of the present qualitative review and meta-analysis is to describe and investigate the impact of study design and methodological features on the correlation between telomere lengths measured in different tissues from the same healthy individual.
Methods: This meta-analysis included studies published from 1988 to 2022. Databases searched included PubMed, Embase, and Web of Science and studies were identified using the keywords "telomere length" and "tissues" or "tissue." A total of 220 articles of 7856 initially identified studies met inclusion criteria for qualitative review, of which 55 met inclusion criteria for meta-analysis in R RESULTS: Studies meeting inclusion criteria for meta-analysis tended to have enhanced demographic and methodological reporting relative to studies only included in the qualitative review. A total of 463 pairwise correlations reported for 4324 unique individuals and 102 distinct tissues were extracted from the 55 studies and subject to meta-analysis, resulting in a significant effect size z = 0.66 (p < 0.0001) and meta-correlation coefficient of r = 0.58. Meta-correlations were significantly moderated by sample size and telomere length measurement methodology, with studies of smaller size and those using hybridization-based analyses exhibiting the largest meta-correlation. Tissue source also significantly moderated the meta-correlation, wherein correlations between samples of a different lineage (e.g., blood vs. non-blood) or collection method (e.g., peripheral vs. surgical) were lower than correlations between samples of the same lineage or collection method.
Conclusion: These results suggest that telomere lengths measured within individuals are generally correlated, but future research should be intentional in selecting a tissue for telomere length measurement that is most biologically relevant to the exposure or outcome investigated and balance this with the feasibility of obtaining the sample in sufficient numbers of individuals.
Competing Interests: Declaration of Competing Interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests:The authors report financial support was provided by the National Institute on Aging. The authors report administrative support was provided by the Tulane University Meta-Analysis Systematic Review Support Program.
(Copyright © 2023. Published by Elsevier B.V.)
Databáze: MEDLINE
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