Muscle fusogens go viral for gene delivery to skeletal muscle.
Autor: | Gibbs DE; Molecular Biology Institute, Department of Microbiology, Immunology and Molecular Genetics, Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, Los Angeles, CA 90095, USA., Pyle AD; Molecular Biology Institute, Department of Microbiology, Immunology and Molecular Genetics, Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address: apyle@mednet.ucla.edu. |
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Jazyk: | angličtina |
Zdroj: | Cell [Cell] 2023 May 11; Vol. 186 (10), pp. 2041-2043. |
DOI: | 10.1016/j.cell.2023.04.021 |
Abstrakt: | Viruses and multinucleated cells rely on fusogens to facilitate the fusion of their membranes. In this issue of Cell, Millay and colleagues demonstrate that replacing viral fusogens with mammalian skeletal muscle fusogens leads to the specific transduction of skeletal muscle and the ability to deliver gene therapy constructs in a therapeutically relevant muscle disease. Competing Interests: Declaration of interests A.D.P. is a co-founder and scientific advisor to MyoGene Bio, San Diego, CA, USA. (Published by Elsevier Inc.) |
Databáze: | MEDLINE |
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