Immunogenicity of quadrivalent meningococcal conjugate vaccine in frequent platelet donors.

Autor:	Desjardins M; Division of Infectious Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.; Division of Infectious Diseases, Centre Hospitalier de l'Université de Montréal, Montréal, QC, Canada., Cunningham P; Division of Infectious Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, MA., Mitre X; Division of Infectious Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, MA., Pierre D; Division of Infectious Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, MA., Montesano C; Division of Infectious Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, MA., Woods T; Division of Infectious Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, MA., Oganezova K; Division of Infectious Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, MA., Krauss JH; Division of Infectious Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, MA., Von SS; Division of Infectious Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, MA., Kupelian JA; Division of Infectious Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, MA., Li X; Division of Infectious Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, MA., Gothing JA; Division of Infectious Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, MA., Kleinjan JA; Division of Infectious Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, MA., Zhou G; Center for Clinical Investigation, Brigham and Women's Hospital, Boston, MA., Piantadosi S; Department of Surgery, Brigham and Women's Hospital, Boston, MA., Sherman AC; Division of Infectious Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, MA., Walsh SR; Division of Infectious Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, MA., Issa NC; Division of Infectious Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, MA., Kaufman RM; Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA., Baden LR; Division of Infectious Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
Jazyk:	angličtina
Zdroj:	Blood [Blood] 2023 Jul 13; Vol. 142 (2), pp. 202-209.
DOI:	10.1182/blood.2022019482
Abstrakt:	Frequent plateletpheresis is associated with severe lymphopenia of uncertain clinical significance. We assessed the functional impact of frequent platelet donations and associated lymphopenia on the response to neoantigens. We conducted a prospective study of 102 platelet donors (HIV uninfected) who were naive to meningococcal vaccination recruited at Brigham and Women's Hospital. One dose of quadrivalent meningococcal conjugate vaccine was administered. Seroresponse was defined as a fourfold increase of serum bactericidal antibody titers and seroprotection was defined as postvaccination titers of ≥1:8, for each of the 4 vaccine antigens (A, C, W, and Y). Mean age of participants was 61 years, 69% were male, and medial number of platelet donations in prior year was 14 (interquartile range, 4-20). Frequent platelet donors had a low CD4 count (14% with ≤200/μL and 34% with ≤350/μL). Seroresponse rates varied from 68% for serogroup Y to 86% for serogroup A and were higher for participants with baseline titers of <1:8. Postvaccination seroprotection rates varied from 76% for serogroup Y to 96% for serogroup A. After adjustments for age, sex, and frequent donations, lower total lymphocyte or lower CD4 counts were not associated with lower responses. These data suggest no impairment by plateletpheresis-associated lymphopenia on response to these neoantigens. This trial was registered at www.clinicaltrials.gov as #NCT04224311. (© 2023 by The American Society of Hematology.)
Databáze:	MEDLINE
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