Visual function in adults born preterm with very low birth weight-A two-country birth cohort study.

Autor: Kulmala M; Population Health Unit, Finnish Institute for Health and Welfare, Helsinki, Finland.; Department of Ophthalmology, Helsinki University Hospital, Helsinki, Finland., Jørgensen APM; Department of Neuromedicine and Movement Science, Norwegian University of Science and Technology (NTNU), Trondheim, Norway., Aakvik KAD; Department of Clinical and Molecular Medicine, NTNU, Trondheim, Norway., Jussinniemi L; Population Health Unit, Finnish Institute for Health and Welfare, Helsinki, Finland.; PEDEGO Research Unit, MRC Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland.; Population Health Unit, Finnish Institute for Health and Welfare, Oulu, Finland., Benum SD; Department of Clinical and Molecular Medicine, NTNU, Trondheim, Norway., Ingvaldsen SH; Department of Neuromedicine and Movement Science, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.; Department of Ophthalmology, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway., Austeng D; Department of Neuromedicine and Movement Science, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.; Department of Ophthalmology, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway., Kajantie E; Population Health Unit, Finnish Institute for Health and Welfare, Helsinki, Finland.; Department of Clinical and Molecular Medicine, NTNU, Trondheim, Norway.; PEDEGO Research Unit, MRC Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland.; Population Health Unit, Finnish Institute for Health and Welfare, Oulu, Finland.; Children's Hospital, Helsinki University Hospital and University of Helsinki, Helsinki, Finland., Evensen KAI; Department of Clinical and Molecular Medicine, NTNU, Trondheim, Norway.; Department of Rehabilitation Science and Health Technology, Oslo Metropolitan University, Oslo, Norway.; Children's Clinic, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway., Majander A; Department of Ophthalmology, Helsinki University Hospital, Helsinki, Finland.; University of Helsinki, Helsinki, Finland., Morken TS; Department of Neuromedicine and Movement Science, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.; Department of Ophthalmology, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.
Jazyk: angličtina
Zdroj: Acta ophthalmologica [Acta Ophthalmol] 2024 Feb; Vol. 102 (1), pp. 49-57. Date of Electronic Publication: 2023 May 12.
DOI: 10.1111/aos.15683
Abstrakt: Purpose: The purpose of the study was to investigate visual function and vision-related general health in adults that were born preterm with very low birth weight (VLBW: birth weight < 1500 g) in their 30s-40s.
Methods: We recruited 137 adults born preterm with VLBW and 158 term-born controls aged 31-43 years from two birth cohorts: the Helsinki Study of Very Low Birth Weight Adults (Finland) and the NTNU Low Birth Weight in a Lifetime Perspective study (Norway). We used neonatal data and measured refraction, best-corrected visual acuity (BCVA) using the Early Treatment Diabetic Retinopathy Study (ETDRS) chart, contrast sensitivity, visual fields, intraocular pressure (IOP), self-reported vision-targeted health status with the National Eye Institute Visual Function Questionnaire-25.
Results: VLBW adults had a lower BCVA ETDRS score than controls: mean (SD) better eye 86.7 (13.4) versus 90.2 (4.4), p = 0.02; mean (SD) worse eye 82.3 (14.9) versus 87.6 (4.6), p = 0.003. VLBW adults also had lower contrast sensitivity thresholds in several spatial frequencies and scored lower than controls in eight out of the 12 subscales of self-reported vision-targeted health status. Refraction, visual fields and IOP were similar between groups. Two VLBW participants were blind. None had been treated for retinopathy of prematurity.
Conclusion: We suggest that lower visual function and vision-related health represent life-long consequences of prematurity and VLBW in the studied 31- to 43-year-old cohort. The underlying mechanisms remain to be determined.
(© 2023 The Authors. Acta Ophthalmologica published by John Wiley & Sons Ltd on behalf of Acta Ophthalmologica Scandinavica Foundation.)
Databáze: MEDLINE
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