Application of Platelet-Rich Plasma as a Stem Cell Treatment - an Attempt to Clarify a Common Public Misconception.

Autor:	Fareez IM; School of Biology, Faculty of Applied Sciences, Universiti Teknologi MARA, Shah Alam, 40450, Selangor, Malaysia., Liew FF; Department of Oral Biology and Biomedical Sciences, Faculty of Dentistry, MAHSA University, Selangor, 42610, Malaysia., Widera D; Stem Cell Biology and Regenerative Medicine Group, School of Pharmacy, University of Reading, Reading, UK., Mayeen NF; Faculty of Biology, Ludwig-Maximilians-University of Munich, Planegg- Martinsried, 82152, Germany.; TotiCell Limited, Dhaka, 1209, Bangladesh., Mawya J; TotiCell Limited, Dhaka, 1209, Bangladesh., Abu Kasim NH; Faculty of Dentistry, University of Malaya, Kuala Lumpur, 50603, Malaysia.; Faculty of Dentistry, University Kebangsaan Malaysia, Kuala Lumpur, 50300, Malaysia., Haque N; TotiCell Limited, Dhaka, 1209, Bangladesh.
Jazyk:	angličtina
Zdroj:	Current molecular medicine [Curr Mol Med] 2024; Vol. 24 (6), pp. 689-701.
DOI:	10.2174/1566524023666230511152646
Abstrakt:	In recent years, there has been a significant increase in the practice of regenerative medicine by health practitioners and direct-to-consumer businesses globally. Among different tools of regenerative medicine, platelet-rich plasma (PRP) and stem cell-based therapies have received considerable attention. The use of PRP, in particular, has gained popularity due to its easy access, simple processing techniques, and regenerative potential. However, it is important to address a common misconception amongst the general public equating to PRP and stem cells due to the demonstrated efficacy of PRP in treating musculoskeletal and dermatological disorders. Notably, PRP promotes regeneration by providing growth factors or other paracrine factors only. Therefore, it cannot replenish or replace the lost cells in conditions where a large number of cells are required to regenerate tissues and/or organs. In such cases, cellbased therapies are the preferred option. Additionally, other tools of regenerative medicine, such as bioprinting, organoids, and mechanobiology also rely on stem cells for their success. Hence, healthcare and commercial entities offering direct-to-customer regenerative therapies should not mislead the public by claiming that the application of PRP is a stem cell-based therapy. Furthermore, it is important for regulatory bodies to strictly monitor these profit-driven entities to prevent them from providing unregulated regenerative treatments and services that claim a broad variety of benefits with little proof of efficacy, safety concerns, and obscure scientific justification. (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.)
Databáze:	MEDLINE
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