Study of 43 SLE patients with autoimmune liver cirrhosis: emphasis on clinical features and differences from lupus without cirrhosis.

Autor: Zhang XY; Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing, China.; Department of Rheumatology and Immunology, Second Hospital of Shanxi Medical University, Taiyuan, China., Zhang YX; Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing, China., Wang ZQ; Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing, China., Zhang XY; Department of Radiology, Peking University People's Hospital, Beijing, China., Zhang X; Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing, China., Jin JY; Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing, China., Li J; Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing, China., Gan YZ; Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing, China., Yang F; Department of Pathology, Peking University People's Hospital, Beijing, China., Liu YM; Second Department of liver disease center, Beijing Youan Hospital, Capital Medical University, Beijing, China., Liu YY; Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing, China.; Department of Rheumatology and Immunology, Beijing Friendship Hospital, Capital Medical University, Beijing, China., Li ZG; Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing, China.
Jazyk: angličtina
Zdroj: International journal of rheumatic diseases [Int J Rheum Dis] 2023 Jul; Vol. 26 (7), pp. 1268-1275. Date of Electronic Publication: 2023 May 11.
DOI: 10.1111/1756-185X.14712
Abstrakt: Objective: To investigate the clinical characteristics of systemic lupus erythematosus accompanied by autoimmune liver cirrhosis (SLE-ALC) patients and differences from the non-cirrhosis group.
Methods: Forty-three patients with SLE-ALC were enrolled in this study from 2653 patients with SLE in Peking University People's Hospital. A descriptive case-control study was performed between SLE-ALC patients and the entry time-matched non-cirrhosis group.
Results: Among the 43 SLE-ALC patients, 41 (95.3%) were female. Eight patients (18.6%) were first found to have cirrhosis and then diagnosed with SLE. Eighteen patients (41.9%) had jaundice and 27 (62.8%) had esophageal and gastric varices. The age of SLE-ALC patients was 51.1 ± 17.2 years, which was significantly older than the non-cirrhosis group (P < 0.001). Lung involvement was more common as initial manifestations in SLE-ALC patients during the SLE course (P=0.027). Compared with the non-cirrhosis group, SLE-ALC patients had worse liver function. A significantly higher rate of hematological system involvement (anemia, leucopenia, and thrombocytopenia) and a higher level of immunoglobulins were observed in SLE-ALC patients (P<0.05). Moreover, SLE-ALC patients displayed a lower positive rate of anti-double-stranded DNA and anti-ribosomal P protein (P<0.05). The most common radiologic manifestations are ascitic fluid (72.1%) and splenomegaly (71.4%) in SLE-ALC patients. Six SLE-ALC patients underwent liver biopsy, and interface hepatitis was present in all patients.
Conclusions: Cirrhosis is rare in SLE patients but is manifested as a unique pattern of clinical features characterized by late-onset age, lung involvement, high immunoglobulins, and impaired liver function.
(© 2023 Asia Pacific League of Associations for Rheumatology and John Wiley & Sons Australia, Ltd.)
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje