The comparative aspects of hystricomorph subplacenta: potential endocrine organ.

Autor: Miglino MA; Department of Surgery, School of Veterinary Medicine and Animal Science (FMVZ-USP), University of São Paulo- SP, Ave. Prof. Dr. Orlando Marques de Paiva, 87, São Paulo, 05508270, São Paulo, Brazil. miglino@usp.br., de Sá Schiavo Matias G; Department of Surgery, School of Veterinary Medicine and Animal Science (FMVZ-USP), University of São Paulo- SP, Ave. Prof. Dr. Orlando Marques de Paiva, 87, São Paulo, 05508270, São Paulo, Brazil., Rigoglio NN; Department of Surgery, School of Veterinary Medicine and Animal Science (FMVZ-USP), University of São Paulo- SP, Ave. Prof. Dr. Orlando Marques de Paiva, 87, São Paulo, 05508270, São Paulo, Brazil., Borghesi J; Department of Surgery, School of Veterinary Medicine and Animal Science (FMVZ-USP), University of São Paulo- SP, Ave. Prof. Dr. Orlando Marques de Paiva, 87, São Paulo, 05508270, São Paulo, Brazil., de Castro Sasahara TH; Department of Surgery, School of Veterinary Medicine and Animal Science (FMVZ-USP), University of São Paulo- SP, Ave. Prof. Dr. Orlando Marques de Paiva, 87, São Paulo, 05508270, São Paulo, Brazil., Del Portal MJI; Department of Animal Physiology, School of Veterinary Medicine, Complutense University of Madrid (UCM), Madrid, Spain., Del Portal JCI; Department of Animal Physiology, School of Veterinary Medicine, Complutense University of Madrid (UCM), Madrid, Spain., Granado GS; Department of Animal Physiology, School of Veterinary Medicine, Complutense University of Madrid (UCM), Madrid, Spain., Ramos SCC; Department of Animal Physiology, School of Veterinary Medicine, Complutense University of Madrid (UCM), Madrid, Spain., de Oliveira MF; Department of Animal Science, Federal University of the Semi-Arid Region (UFERSA), Mossoro, Brazil., Conley AJ; Department of Population Health and Reproduction, School of Veterinary Medicine School of Veterinary Medicine, University of California UC-Davis, 3223 VM3B, Sacramento, California, USA.
Jazyk: angličtina
Zdroj: BMC zoology [BMC Zool] 2021 May 19; Vol. 6 (1), pp. 16. Date of Electronic Publication: 2021 May 19.
DOI: 10.1186/s40850-021-00074-w
Abstrakt: Background: The placenta of hystricomorph rodents, lagomorphs and some primates includes an unusual structure, termed a subplacenta, which essentially consists of trophoblastic cells located deep to the central implantation site within the area of decidualization. It has been suggested that the subplacenta is functionally important, although considerable controversy remains on the issue. In this context, our objective was to compare the architecture and structure of the subplacentas of different hystricomorph species, to investigate the possibility that it is active in hormone synthesis.
Methods: In total, the placentas of 3 capybaras (Hydrochaeris hydrochaeris), 2 pacas (Agouti paca), 5 agoutis (Dasyprocta leporina), 5 rock cavies (Kerodon rupestris) and 3 guinea pigs (Cavia porcellus) at different stages of pregnancy (early, middle and near term) were used for gross and microscopic examination. This included the preparation of latex injection casts, immunohistochemistry for steroidogenic enzymes, scanning and transmission electron microscopy. Tissue steroid concentrations were also determined.
Results: The gross morphology and microvascular arrangement of the subplacentas were similar among the hystricomorphs studied including ultra-structural verification of cytotrophoblast and syncytiotrophoblast in all species. In guinea pigs, trophoblast cells exhibited characteristics consistent with intense metabolic and secretory activity in general. However, immuno-histochemical evidence also indicated that subplacental trophoblast expressed key steroidogenic enzymes, mainly in the chorionic villus region, consistent with tissue steroid concentrations.
Conclusions: The subplacentas within placentas of hystricomorph rodent species are structurally similar and, in guinea pigs, have potential for steroid hormone secretion from, at least the early stages of pregnancy.
(© 2021. The Author(s).)
Databáze: MEDLINE
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