In Vitro Study of Cytostatic Activity of Baicalin, Baicalein, and Chlorophyllipt on HeLa-v Cell Line.

Autor: Boyko NN; Peoples' Friendship University of Russia, RUDN University), Moscow, Russia. boykoniknik@gmail.com., Novikov OO; Peoples' Friendship University of Russia, RUDN University), Moscow, Russia., Zhilyakova ET; Belgorod State National Research University, Belgorod, Russia., Pisarev DI; Peoples' Friendship University of Russia, RUDN University), Moscow, Russia., Nadezhdin SV; Belgorod State National Research University, Belgorod, Russia., Zubareva EV; Belgorod State National Research University, Belgorod, Russia., Lysenko AS; Belgorod State National Research University, Belgorod, Russia., Lapshina EG; Belgorod State National Research University, Belgorod, Russia., Yagnikov SA; Peoples' Friendship University of Russia, RUDN University), Moscow, Russia., Nikitchenko DV; Peoples' Friendship University of Russia, RUDN University), Moscow, Russia.
Jazyk: angličtina
Zdroj: Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2023 Apr; Vol. 174 (6), pp. 738-740. Date of Electronic Publication: 2023 May 12.
DOI: 10.1007/s10517-023-05782-6
Abstrakt: Cytostatic activity of baicalin, baicalein, and neogalenical drug Chlorophyllipt was studied in vitro on HeLa-v cells. Standard samples of Eucalimin, baicalin, and baicalein, as well as Chlorophyllipt and paclitaxel (reference drug Taxacad) were used. The cell deaths were determined by MTT assay in a Multiskan FC microplate reader with incubator. The effective inhibition concentration (IC 50 ) of the tested substances were: paclitaxel (4.0±0.4 μM)-baicalein (10.5±1.1 μM)-baicalin (16.5±1.7 μM)-sum of euglobals in Chlorophyllipt (24.1±2.5 μM). Chlorophyllipt was found to exhibit cytostatic activity. Cytostatic activity of baicalein, baicalin, and Chlorophyllipt was lower than cytostatic activity of the reference drug by 2.6, 4.1, and 6 times, respectively. The prospects of further evaluation of the synergetic effect of baicalin, baicalein, and chlorophyllipt used in combinations with different cytostatic agents for finding the most effective combination have been shown.
(© 2023. Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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