Identification of Chlamydia trachomatis genotypes in newborns with respiratory distress.

Autor:	González-Fernández MD; Departamento de Microbiología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Ciudad de México, Mexico. Electronic address: darkliliums@gmail.com., Escarcega-Tame MA; Laboratorio de Virología, Instituto Nacional de Perinatología, Ciudad de México, Mexico. Electronic address: escar_tame7@hotmail.com., López-Hurtado M; Laboratorio de Virología, Instituto Nacional de Perinatología, Ciudad de México, Mexico. Electronic address: diaclaro2000@yahoo.com.mx., Flores-Salazar VR; Laboratorio de Virología, Instituto Nacional de Perinatología, Ciudad de México, Mexico. Electronic address: f_rox77@hotmail.com., Escobedo-Guerra MR; Laboratorio de Virología, Instituto Nacional de Perinatología, Ciudad de México, Mexico. Electronic address: syramses@yahoo.com., Giono-Cerezo S; Departamento de Microbiología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Ciudad de México, Mexico. Electronic address: sgiono@yahoo.com., Guerra-Infante FM; Departamento de Microbiología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Ciudad de México, Mexico; Laboratorio de Virología, Instituto Nacional de Perinatología, Ciudad de México, Mexico. Electronic address: fguerra_96@yahoo.com.
Jazyk:	angličtina
Zdroj:	Anales de pediatria [An Pediatr (Engl Ed)] 2023 Jun; Vol. 98 (6), pp. 436-445. Date of Electronic Publication: 2023 May 09.
DOI:	10.1016/j.anpede.2023.04.010
Abstrakt:	Introduction: One hundred thirty million Chlamydia trachomatis infections are reported worldwide each year. Nineteen serotypes of this pathogen can cause infection in pregnant women and neonates. The distribution of these genotypes in newborns with respiratory infections in Mexico is unknown. Material and Methods: We tested 1062 bronchial lavage samples from neonates with respiratory distress syndrome for Chlamydia infection. The diagnosis of Chlamydia was made by plasmid detection with an in-house PCR assay, and genotypes were identified using a PCR-RFLP assay for the ompA gene. Results: The genotyping of 40 strains identified 14 as I/Ia (35%), 13 as E (32.5%), 7 as D (17.5%), 5 as F (12.5%), and 1 as L2 (2.5%). The relative risk analysis showed that genotype D was associated with neonatal sepsis (RR, 5.83; 95% confidence interval [CI], 1.51-25.985; P < .02), while the I/Ia genotype was significantly associated with chorioamnionitis in the mother (2.8; 95% CI, 1.4-5.5; P < .05). Conclusions: Although C. trachomatis genotypes I/Ia and E of were the strains involved most frequently in respiratory infections in Mexican neonates, 80% of patients with genotype F developed respiratory disease. In contrast, genotype D was associated with neonatal sepsis, and genotype I/Ia with chorioamnionitis. (Copyright © 2023 Asociación Española de Pediatría. Published by Elsevier España, S.L.U. All rights reserved.)
Databáze:	MEDLINE
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