Narrowing the translational research gap by aligning replication concepts in basic and clinical neuroscience.

Autor: Lewis AS; Departments of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Neurology, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Vanderbilt Kennedy Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Vanderbilt Brain Institute and Vanderbilt University, Nashville, TN 37232, USA; Vanderbilt Center for Addiction Research, Vanderbilt University, Nashville, TN 37232, USA. Electronic address: alan.s.lewis@vumc.org., Nobis WP; Neurology, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Vanderbilt Kennedy Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Vanderbilt Brain Institute and Vanderbilt University, Nashville, TN 37232, USA.
Jazyk: angličtina
Zdroj: Journal of neuroscience methods [J Neurosci Methods] 2023 May 15; Vol. 392, pp. 109878. Date of Electronic Publication: 2023 May 09.
DOI: 10.1016/j.jneumeth.2023.109878
Abstrakt: Replicability and reproducibility are widely considered to be cornerstones of valid scientific research. Yet, the elements of replication in fundamental neuroscience studies do not fully overlap with the process of replication in clinical neuroscience involving patients. Here we discuss how better aligning the concept of replication across this translational spectrum might enhance the rate at which basic findings in the organization and function of the nervous system are leveraged to develop new treatments for psychiatric and neurological disorders.
Competing Interests: Declaration of Competing Interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Alan S. Lewis reports financial support was provided by National Institute of Mental Health. William P. Nobis reports financial support was provided by National Center for Advancing Translational Sciences.
(Copyright © 2023 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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