Programming Levels and Speech Perception in Pediatric Cochlear Implant Recipients With Enlarged Vestibular Aqueduct or GJB2 Mutation.

Autor:	Jahn KN; Department of Speech, Language, and Hearing, University of Texas at Dallas, Richardson, Texas., Morse-Fortier C; Audiology Division, Massachusetts Eye and Ear., Griffin AM, Faller D; Department of Otolaryngology and Communication Enhancement, Boston Children's Hospital., Cohen MS; Department of Otolaryngology-Head and Neck Surgery, Harvard Medical School, Boston, Massachusetts., Kenna MA, Doney E; Audiology Division, Massachusetts Eye and Ear., Arenberg JG
Jazyk:	angličtina
Zdroj:	Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology [Otol Neurotol] 2023 Jun 01; Vol. 44 (5), pp. e273-e280.
DOI:	10.1097/MAO.0000000000003879
Abstrakt:	Objective: To determine the relationship between hearing loss etiology, cochlear implant (CI) programming levels, and speech perception performance in a large clinical cohort of pediatric CI recipients. Study Design: Retrospective chart review. Setting: Tertiary care hospitals. Patients: A total of 136 pediatric CI recipients (218 ears) were included in this study. All patients had diagnoses of either enlarged vestibular aqueduct (EVA) or GJB2 (Connexin-26) mutation confirmed via radiographic data and/or genetic reports. All patients received audiologic care at either Boston Children's Hospital or Massachusetts Eye and Ear in Boston, MA, between the years 1999 and 2020. Main Outcome Measures: Electrode impedances and programming levels for each active electrode and speech perception scores were evaluated as a function of etiology (EVA or GJB2 mutation). Results: Children with EVA had significantly higher impedances and programming levels (thresholds and upper stimulation levels) than the children with GJB2 mutation. Speech perception scores did not differ as a function of etiology in this sample; rather, they were positively correlated with duration of CI experience (time since implantation). Conclusions: Differences in electrode impedances and CI programming levels suggest that the electrode-neuron interface varies systematically as a function of hearing loss etiology in pediatric CI recipients with EVA and those with GJB2 mutation. Time with the CI was a better predictor of speech perception scores than etiology, suggesting that children can adapt to CI stimulation with experience. Competing Interests: The authors disclose no conflicts of interest. (Copyright © 2023, Otology & Neurotology, Inc.)
Databáze:	MEDLINE
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