Metabolic Adaptations Correlated with Antibody Response after Immunization with Inactivated SARS-CoV-2 in Brazilian Subjects.

Autor: de Souza Nogueira J; Histocompatibility and Cryopreservation Laboratory, IBRAG, Rio de Janeiro State University, CEP 20950-003 Rio de Janeiro, Rio de Janeiro, Brazil., Santos-Rebouças CB; Department of Genetics, IBRAG, Rio de Janeiro State University, CEP 20550-013 Rio de Janeiro, Rio de Janeiro, Brazil., Piergiorge RM; Department of Genetics, IBRAG, Rio de Janeiro State University, CEP 20550-013 Rio de Janeiro, Rio de Janeiro, Brazil., Valente AP; CENABIO I, Institute of Medical Biochemistry, CNRMN, BioNMR, Federal University of Rio de Janeiro, CEP 21941-902 Rio de Janeiro, Rio de Janeiro, Brazil., Gama-Almeida MC; LeBioME-Bioactives, Mitochondria and Placental Metabolism Core, Institute of Nutrition Josué de Castro, Federal University of Rio de Janeiro, CEP 21941-902 Rio de Janeiro, Rio de Janeiro, Brazil., El-Bacha T; LeBioME-Bioactives, Mitochondria and Placental Metabolism Core, Institute of Nutrition Josué de Castro, Federal University of Rio de Janeiro, CEP 21941-902 Rio de Janeiro, Rio de Janeiro, Brazil., Lopes Moreira ML; UNADIG, Oswaldo Cruz Foundation, Fiocruz-RJ, CEP 21040-360 Rio de Janeiro, Rio de Janeiro, Brazil., Baptista Marques BS; UNADIG, Oswaldo Cruz Foundation, Fiocruz-RJ, CEP 21040-360 Rio de Janeiro, Rio de Janeiro, Brazil., de Siqueira JR; UNADIG, Oswaldo Cruz Foundation, Fiocruz-RJ, CEP 21040-360 Rio de Janeiro, Rio de Janeiro, Brazil., de Carvalho EM; UNADIG, Oswaldo Cruz Foundation, Fiocruz-RJ, CEP 21040-360 Rio de Janeiro, Rio de Janeiro, Brazil., da Costa Ferreira O Jr; Molecular Virology Laboratory, Federal University of Rio de Janeiro, CEP 21941-902 Rio de Janeiro, Rio de Janeiro, Brazil., Porto LC; Histocompatibility and Cryopreservation Laboratory, IBRAG, Rio de Janeiro State University, CEP 20950-003 Rio de Janeiro, Rio de Janeiro, Brazil., Kelly da Silva Fidalgo T; Department of Preventive and Community Dentistry, Dental School, Rio de Janeiro State University, CEP 20551-030 Rio de Janeiro, Rio de Janeiro, Brazil., Costa Dos Santos G Jr; Department of Genetics, IBRAG, Rio de Janeiro State University, CEP 20550-013 Rio de Janeiro, Rio de Janeiro, Brazil.
Jazyk: angličtina
Zdroj: Journal of proteome research [J Proteome Res] 2023 Jun 02; Vol. 22 (6), pp. 1908-1922. Date of Electronic Publication: 2023 May 11.
DOI: 10.1021/acs.jproteome.3c00014
Abstrakt: The adsorbed vaccine SARS-CoV-2 (inactivated) produced by Sinovac (SV) was the first vaccine against COVID-19 to be used in Brazil. To understand the metabolic effects of SV in Brazilian subjects, NMR-based metabolomics was used, and the immune response was studied in Brazilian subjects. Forty adults without (group - , n = 23) and with previous COVID-19 infection (group + , n = 17) were followed-up for 90 days postcompletion of the vaccine regimen. After 90 days, our results showed that subjects had increased levels of lipoproteins, lipids, and N -acetylation of glycoproteins (NAG) as well as decreased levels of amino acids, lactate, citrate, and 3-hydroxypropionate. NAG and threonine were the highest correlated metabolites with N and S proteins, and neutralizing Ab levels. This study sheds light on the immunometabolism associated with the use of SV in Brazilian subjects from Rio de Janeiro and identifies potential metabolic markers associated with the immune status.
Databáze: MEDLINE
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