Effects of hunger on neuronal histone modifications slow aging in Drosophila .

Autor: Weaver KJ; Department of Molecular and Integrative Physiology and Geriatrics Center, Biomedical Sciences and Research Building, University of Michigan, Ann Arbor, MI 48109, USA., Holt RA; College of Literature, Science, and the Arts, Biomedical Sciences and Research Building, University of Michigan, Ann Arbor, MI 48109, USA., Henry E; Program in Cellular and Molecular Biology, University of Michigan, Ann Arbor, MI 48109, USA., Lyu Y; Department of Molecular Biology & Biochemistry, Rutgers University, Piscataway, NJ 08855, USA., Pletcher SD; Department of Molecular and Integrative Physiology and Geriatrics Center, Biomedical Sciences and Research Building, University of Michigan, Ann Arbor, MI 48109, USA.
Jazyk: angličtina
Zdroj: Science (New York, N.Y.) [Science] 2023 May 12; Vol. 380 (6645), pp. 625-632. Date of Electronic Publication: 2023 May 11.
DOI: 10.1126/science.ade1662
Abstrakt: Hunger is an ancient drive, yet the molecular nature of pressures of this sort and how they modulate physiology are unknown. We find that hunger modulates aging in Drosophila . Limitation of branched-chain amino acids (BCAAs) or activation of hunger-promoting neurons induced a hunger state that extended life span despite increased feeding. Alteration of the neuronal histone acetylome was associated with BCAA limitation, and preventing these alterations abrogated the effect of BCAA limitation to increase feeding and extend life span. Hunger acutely increased feeding through usage of the histone variant H3.3, whereas prolonged hunger seemed to decrease a hunger set point, resulting in beneficial consequences for aging. Demonstration of the sufficiency of hunger to extend life span reveals that motivational states alone can be deterministic drivers of aging.
Databáze: MEDLINE
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