Novel Bis-pyrazoline Fluorescent Probe for Cu 2+ and Fe 3+ Detection and Application in Cell Imaging.

Autor: Yang YS; School of Petrochemical Engineering & Key Laboratory of Low Carbon Energy and Chemical Engineering of Gansu, Lanzhou University of Technology, Lanzhou, 730050, China. yangyunshang@tom.com., Wang FN; School of Petrochemical Engineering & Key Laboratory of Low Carbon Energy and Chemical Engineering of Gansu, Lanzhou University of Technology, Lanzhou, 730050, China., Zhang YP; School of Petrochemical Engineering & Key Laboratory of Low Carbon Energy and Chemical Engineering of Gansu, Lanzhou University of Technology, Lanzhou, 730050, China. yingpengzhang@126.com., Yang F; School of Petrochemical Engineering & Key Laboratory of Low Carbon Energy and Chemical Engineering of Gansu, Lanzhou University of Technology, Lanzhou, 730050, China., Xue JJ; State Key Laboratory of Applied Organic Chemistry & College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, 730000, China.
Jazyk: angličtina
Zdroj: Journal of fluorescence [J Fluoresc] 2024 Jan; Vol. 34 (1), pp. 159-167. Date of Electronic Publication: 2023 May 11.
DOI: 10.1007/s10895-023-03213-3
Abstrakt: A fluorescent probe Y((1,1'-([1,1'-biphenyl]-4,4'-diylbis(3-(2-hydroxyphenyl)-4,5-dihydro-1H-pyrazole-5,1-diyl)) bis(ethan-1-one))) was designed and synthesized, which could be used to Cu 2+ and Fe 3+ sensors. Through the study of optical properties, the probe Y shows good selectivity and sensitivity to Cu 2+ and Fe 3+ in aqueous tetrahydrofuran solution [10.0 mM HEPES, pH 7.4, THF-H 2 O = 9:1(v/v)] with has excellent anti-interference performance, and its detection limits were 0.931 uΜ for Cu 2+ and 0.401uΜ for Fe 3+ . The coordination mechanism of probe Y with Cu 2+ and Fe 3+ was speculated and verified at DFT level and HRNM. By Hela cytotoxicity and imaging tests, probe Y not only has good biocompatibility, but also can be used for sensing Cu 2+ in cells.
(© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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