Pharmacokinetics and Pharmacodynamics of Lansoprazole/Sodium Bicarbonate Immediate-release Capsules in Healthy Chinese Subjects: An Open, Randomized, Controlled, Crossover, Single-, and Multiple-dose Trial.
Autor: | Yu L; Department of Pharmacy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China.; Hubei Province Clinical Research Center for Precision Medicine for Critical Illness, Union Hospital, Wuhan, People's Republic of China., Zhai X; Department of Pharmacy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China.; Hubei Province Clinical Research Center for Precision Medicine for Critical Illness, Union Hospital, Wuhan, People's Republic of China., Wu S; Department of Pharmacy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China.; Hubei Province Clinical Research Center for Precision Medicine for Critical Illness, Union Hospital, Wuhan, People's Republic of China., Cao P; Department of Pharmacy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China.; Hubei Province Clinical Research Center for Precision Medicine for Critical Illness, Union Hospital, Wuhan, People's Republic of China., Deng Y; Department of Pharmacy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China.; Hubei Province Clinical Research Center for Precision Medicine for Critical Illness, Union Hospital, Wuhan, People's Republic of China., Yang Q; Department of Pharmacy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China., Zhang Q; Department of Pharmacy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China.; Hubei Province Clinical Research Center for Precision Medicine for Critical Illness, Union Hospital, Wuhan, People's Republic of China., Wu J; Department of Scientific Research, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China., Deng Y; Department of Scientific Research, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China., Liu Q; Department of Scientific Research, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China., Zhang Y; Department of Pharmacy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China.; Hubei Province Clinical Research Center for Precision Medicine for Critical Illness, Union Hospital, Wuhan, People's Republic of China. |
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Jazyk: | angličtina |
Zdroj: | Clinical pharmacology in drug development [Clin Pharmacol Drug Dev] 2023 Sep; Vol. 12 (9), pp. 902-910. Date of Electronic Publication: 2023 May 11. |
DOI: | 10.1002/cpdd.1251 |
Abstrakt: | Proton pump inhibitors (PPIs) differ in onset of action and bioavailability. This trial was conducted to investigate the pharmacokinetics and pharmacodynamics of an immediate-release capsule formulation containing lansoprazole 30 mg and sodium bicarbonate 1100 mg (T preparation) in healthy Chinese subjects. This was an open, single-center, randomized, single and multiple oral doses, and two-period crossover study in 30 healthy subjects. After single- and multiple-dose oral administration, blood samples were obtained and lansoprazole concentration in serum was measured for pharmacokinetic analysis. Meanwhile, the intragastric pH was monitored continuously to evaluate the pharmacodynamics of the investigational drugs. The T (© 2023, The American College of Clinical Pharmacology.) |
Databáze: | MEDLINE |
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